Evidence map›Paper›PMID 39112530›Full record

ArticleScientific reports2024

Central neurodegeneration in Kennedy's disease accompanies peripheral motor dysfunction.

Sicong Tu, Tiffany Li, Antonia S Carroll, Colin J Mahoney, William Huynh, Susanna B Park, Robert Henderson, Steve Vucic, Matthew C Kiernan, Cindy S-Y Lin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sicong TuBrain and Mind Centre, Faculty of Medicine and Health, The University of Sydney, Sydney, 2050, Australia. sicong.tu@sydney.edu.au.
Tiffany LiBrain and Mind Centre, Faculty of Medicine and Health, The University of Sydney, Sydney, 2050, Australia.
Antonia S CarrollBrain and Mind Centre, Faculty of Medicine and Health, The University of Sydney, Sydney, 2050, Australia.
Colin J MahoneyBrain and Mind Centre, Faculty of Medicine and Health, The University of Sydney, Sydney, 2050, Australia.
William HuynhBrain and Mind Centre, Faculty of Medicine and Health, The University of Sydney, Sydney, 2050, Australia.
Susanna B ParkBrain and Mind Centre, Faculty of Medicine and Health, The University of Sydney, Sydney, 2050, Australia.
Robert HendersonRoyal Brisbane and Women's Hospital, University of Queensland, Brisbane, 4029, Australia.
Steve VucicBrain and Mind Centre, Faculty of Medicine and Health, The University of Sydney, Sydney, 2050, Australia.
Matthew C KiernanBrain and Mind Centre, Faculty of Medicine and Health, The University of Sydney, Sydney, 2050, Australia.
Cindy S-Y LinBrain and Mind Centre, Faculty of Medicine and Health, The University of Sydney, Sydney, 2050, Australia. cindy.lin@sydney.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal and bulbar muscular atrophy (SBMA), or Kennedy's disease (KD), is a rare hereditary neuromuscular disorder demonstrating commonalities with amyotrophic lateral sclerosis (ALS). The current study aimed to define functional and central nervous system abnormalities associated with SBMA pathology, their interaction, and to identify novel clinical markers for quantifying disease activity. 27 study participants (12 SBMA; 8 ALS; 7 Control) were recruited. SBMA patients underwent comprehensive motor and sensory functional assessments, and neurophysiological testing. All participants underwent whole-brain structural and diffusion MRI. SBMA patients demonstrated marked peripheral motor and sensory abnormalities across clinical assessments. Increased abnormalities on neurological examination were significantly associated with increased disease duration in SBMA patients (R

Indexed as

Bulbo-Spinal Atrophy, X-LinkedAdultAgedAmyotrophic Lateral SclerosisBrainFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedWhite MatterAmyotrophic lateral sclerosisDiffusion-weighted imagingKennedy’s diseaseMRIPeripheral nerveSpinobulbar muscular atrophy

Identifiers

PMID39112530
PMCPMC11306389

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.