Evidence map›Paper›PMID 39112510›Full record

ReviewNPJ systems biology and applications2024

On the salient limitations of the methods of assembly theory and their classification of molecular biosignatures.

Abicumaran Uthamacumaran, Felipe S Abrahão, Narsis A Kiani, Hector Zenil

Abstract readReview
In one paragraph

Review in NPJ systems biology and applications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. A Metric for the Entropic Purpose of a System.Entropy (Basel, Switzerland) · 2025
    Article
  3. Article
  4. Article
  5. Assembly Theory: What It Does and What It Does Not Do.Journal of molecular evolution · 2024
    Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Abicumaran UthamacumaranDepartment of Physics and Psychology (Alumni), Concordia University, Montreal, Canada.
Felipe S AbrahãoCentre for Logic, Epistemology and the History of Science, University of Campinas (UNICAMP), Campinas, Brazil.ORCID http://orcid.org/0000-0001-7314-6543
Narsis A KianiDepartment of Oncology-Pathology, Center for Molecular Medicine, Karolinska Institutet, Solna, Sweden.
Hector ZenilAlgorithmic Dynamics Lab, Karolinska Institutet, Solna, Sweden. hector.zenil@cs.ox.ac.uk.ORCID http://orcid.org/0000-0003-0634-4384

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We demonstrate that the assembly pathway method underlying assembly theory (AT) is an encoding scheme widely used by popular statistical compression algorithms. We show that in all cases (synthetic or natural) AT performs similarly to other simple coding schemes and underperforms compared to system-related indexes based upon algorithmic probability that take into account statistical repetitions but also the likelihood of other computable patterns. Our results imply that the assembly index does not offer substantial improvements over existing methods, including traditional statistical ones, and imply that the separation between living and non-living compounds following these methods has been reported before.

Indexed as

AlgorithmsComputational Biology

Identifiers

PMID39112510
PMCPMC11306634

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.