ArticleNature communications2024
Engineering new-to-nature biochemical conversions by combining fermentative metabolism with respiratory modules.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed.
- Hierarchical Flux-Protection Engineering Stabilizes Oxidation-Prone Metabolic Nodes for High-Level Curcumin Biosynthesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The potential of syngas as a central mediator for a carbon-agnostic circular economy.Nature communications · 2026Review
- Bioelectrode Healing via Engineered Electrode Reconstruction on Biofilms under Strong Acid and Ultrahigh Current Density.Chem & bio engineering · 2026Article
- Anaerobic metabolic evolution for homotypic L-valine fermentation.Nature communications · 2026Article
- Redox engineering of thermophilic fungusMycology · 2026Article
- A blueprint for designing the next-generation of synthetic CNature communications · 2025Review
- Mixotrophy for carbon-conserving waste upcycling.PLoS computational biology · 2025Article
- Physiology-informed use of Cupriavidus necator in biomanufacturing: a review of advances and challenges.Microbial cell factories · 2025Review
- Seven critical challenges in synthetic one-carbon assimilation and their potential solutions.FEMS microbiology reviews · 2025Review
- Humin oxidation drives microbial dehalogenation in oligotrophic environments.The ISME journal · 2025Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
Anaerobic microbial fermentations provide high product yields and are a cornerstone of industrial bio-based processes. However, the need for redox balancing limits the array of fermentable substrate-product combinations. To overcome this limitation, here we design an aerobic fermentative metabolism that allows the introduction of selected respiratory modules. These can use oxygen to re-balance otherwise unbalanced fermentations, hence achieving controlled respiro-fermentative growth. Following this design, we engineer and characterize an obligate fermentative Escherichia coli strain that aerobically ferments glucose to stoichiometric amounts of lactate. We then re-integrate the quinone-dependent glycerol 3-phosphate dehydrogenase and demonstrate glycerol fermentation to lactate while selectively transferring the surplus of electrons to the respiratory chain. To showcase the potential of this fermentation mode, we direct fermentative flux from glycerol towards isobutanol production. In summary, our design permits using oxygen to selectively re-balance fermentations. This concept is an advance freeing highly efficient microbial fermentation from the limitations imposed by traditional redox balancing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.