ArticleJournal of the American College of Cardiology2024
Myocardial Strain Measured by Cardiac Magnetic Resonance Predicts Cardiovascular Morbidity and Death.
Article in Journal of the American College of Cardiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Left ventricular remodeling by cardiac magnetic resonance in children with advanced chronic kidney disease: an analysis of the Chronic Kidney Disease in Children (CKiD) study.Pediatric nephrology (Berlin, Germany) · 2026Article
- Right Heart Strain in Acute Myocardial Infarction: Toward an Integrated Atrioventricular Perspective.Journal of magnetic resonance imaging : JMRI · 2026Article
- Clinical value of gated SPECT-derived left ventricular strain and reserve: derivation of quantitative cutoffs.European journal of nuclear medicine and molecular imaging · 2026Article
- Mechanical signatures of left ventricular ejection fraction and mass index in a community cohort (ACE 1950).The international journal of cardiovascular imaging · 2026Article
- Genetic analysis of imaging-derived phenotypes.Nature reviews. Genetics · 2026Review
- Four-dimensional left ventricular motion clustering reveals cardiovascular phenotypes at population scale.Scientific reports · 2026Article
- Clinical Phenotypes in Hypertension: A Data-Driven Approach to Risk Stratification.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Association Between Regional Cardiac Radiation Dose and Magnetic Resonance Imaging Myocardial Contractility Parameters: A Prospective Pilot Study.Tomography (Ann Arbor, Mich.) · 2026Article
- Myocardial fibrosis and strain impairment in treatment-naïve cancer patients: insights into cancer-related myocardial remodeling from a prospective case-control CMR study.La Radiologia medica · 2026Article
- Cardiac Magnetic Resonance Imaging in Alcohol-Related Myocardial Injury: A Comprehensive Review.Reviews in cardiovascular medicine · 2026Review
- Prognostic stratification of cardiovascular risk and cardiac remodeling in prediabetes: a multimodal analysis comparing ADA and WHO/IEC diagnostic criteria.Cardiovascular diabetology · 2026Observational
- ZeCardioAI: combining zebrafish, AI, and xAI for an in-depth cardiac phenotyping platform.Briefings in bioinformatics · 2026Article
- Associations of Integrated Left Ventricular Myocardial Strain Metrics and Incident Atrial Fibrillation.CJC open · 2026Article
- Unsupervised Cardiac Video Translation Via Motion Feature Guided Diffusion Model.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2026Article
- Cardiac magnetic resonance characteristics and prognostic associations of hypertension-mediated left ventricular hypertrophy.European heart journal. Imaging methods and practice · 2026Article
- Evaluation and follow-up of left ventricular function in children with Mycoplasma pneumoniae pneumonia using cardiac magnetic resonance feature tracking.Cardiology journal · 2026Article
- Incremental predictive value of CMR phenotyping for major adverse cardiovascular events: an interpretable machine learning study from UK Biobank.Frontiers in medicine · 2026Article
- Early diagnosis of cardiac involvement in Anderson-Fabry disease using cardiac MRI parameters.Future cardiology · 2025Review
- Impact of left ventricular dilatation on biventricular function and deformation in diabetes mellitus with reduced ejection fraction: a CMR feature tracking study.Cardiovascular diabetology · 2025Article
- Global Myocardial Wall Thickness in Transfusion-Dependent Thalassemia: A Cross-Sectional MRI Analysis.Diagnostics (Basel, Switzerland) · 2025Article
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Authors and funding
13 authors.
Funding
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Abstract
backgroundMyocardial strain using cardiac magnetic resonance (CMR) is a sensitive marker for predicting adverse outcomes in many cardiac disease states, but the prognostic value in the general population has not been studied conclusively.
objectivesThe goal of this study was to assess the independent prognostic value of CMR feature tracking (FT)-derived LV global longitudinal (GLS), circumferential (GCS), and radial strain (GRS) metrics in predicting adverse outcomes (heart failure, myocardial infarction, stroke, and death).
methodsParticipants from the UK Biobank population imaging study were included. Univariable and multivariable Cox models were used for each outcome and each strain marker (GLS, GCS, GRS) separately. The multivariable models were tested with adjustment for prognostically important clinical features and conventional global LV imaging markers relevant for each outcome.
resultsOverall, 45,700 participants were included in the study (average age 65 ± 8 years), with a median follow-up period of 3 years. All univariable and multivariable models demonstrated that lower absolute GLS, GCS, and GRS were associated with increased incidence of heart failure, myocardial infarction, stroke, and death. All strain markers were independent predictors (incrementally above some respective conventional LV imaging markers) for the morbidity outcomes, but only GLS predicted death independently: (HR: 1.18; 95% CI: 1.07-1.30).
conclusionsIn the general population, LV strain metrics derived using CMR-FT in radial, circumferential, and longitudinal directions are strongly and independently predictive of heart failure, myocardial infarction, and stroke, but only GLS is independently predictive of death in an adult population cohort.
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