Evidence map›Paper›PMID 39111825›Full record

ArticleGenes & development2024

A developmental mechanism to regulate alternative polyadenylation in an adult stem cell lineage.

Lorenzo Gallicchio, Neuza R Matias, Fabián Morales-Polanco, Iliana Nava, Sarah Stern, Yi Zeng, Margaret T Fuller

Abstract read
In one paragraph

Article in Genes & development, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Lorenzo GallicchioDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, California 94035, USA.ORCID 0000-0002-5040-0139
Neuza R MatiasDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, California 94035, USA.ORCID 0000-0003-1548-037X
Fabián Morales-PolancoDepartment of Biology, Stanford University School of Humanities and Sciences, Stanford, California 94035, USA.ORCID 0000-0002-7695-3081
Iliana NavaDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, California 94035, USA.
Sarah SternDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, California 94035, USA.ORCID 0000-0002-6518-7289
Yi ZengDepartment of Genetics, Stanford University School of Medicine, Stanford, California 94035, USA.
Margaret T FullerDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, California 94035, USA; mtfuller@stanford.edu.ORCID 0000-0002-3804-4987

Funding

GENETICS TRAINING PROGRAM FOR PHD CANDIDATEST32GM007790 · NIGMS · STANFORD UNIVERSITY · PI BRUNET, ANNE, KINGSLEY, DAVID M · 1985 to 2020
$12.8M
Regulation of proliferation and differentiation in the male germ line adult stem cell lineageR35GM136433 · NIGMS · STANFORD UNIVERSITY · PI MARGARET T FULLER · 2020 to 2026
$5.9M
Nikon A1Rsi resonant spectral confocal microscopeS10OD010580 · OD · STANFORD UNIVERSITY · PI FULLER, MARGARET T · 2013 to 2013
$377k
NIGMS NIH HHS R35 GM136433NIGMS NIH HHS T32 GM007790NIH HHS S10 OD010580
6 · The paper itself

Abstract

Alternative cleavage and polyadenylation (APA) often results in production of mRNA isoforms with either longer or shorter 3' UTRs from the same genetic locus, potentially impacting mRNA translation, localization, and stability. Developmentally regulated APA can thus make major contributions to cell type-specific gene expression programs as cells differentiate. During

Indexed as

Cell LineagePolyadenylationSpermatocytesSpermatogenesisAdult Stem CellsAnimalsDrosophila melanogasterDrosophila ProteinsGene Expression Regulation, DevelopmentalMalemRNA Cleavage and Polyadenylation FactorsSpermatogoniaDrosophila ProteinsmRNA Cleavage and Polyadenylation Factorsalternative polyadenylationcellular differentiationcleavage factor complex IIdevelopmentDrosophilamRNA processingspermatogenesis

Identifiers

PMID39111825
PMCPMC11368245

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.