Evidence map›Paper›PMID 39111319›Full record

ArticleCell genomics2024

Stable and robust Xi and Y transcriptomes drive cell-type-specific autosomal and Xa responses in vivo and in vitro in four human cell types.

Laura V Blanton, Adrianna K San Roman, Geryl Wood, Ashley Buscetta, Nicole Banks, Helen Skaletsky, Alexander K Godfrey, Thao T Pham, Jennifer F Hughes, Laura G Brown and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell genomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Immune System Development-Pro Tips for Paediatricians.Acta paediatrica (Oslo, Norway : 1992) · 2026
    Review
  4. Article
  5. Sex Steroid Hormone Regulation of T-Cell Function and Antitumor Immunity.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Transcriptomic Convergence and the Female Protective Effect in Autism.bioRxiv : the preprint server for biology · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Laura V BlantonWhitehead Institute, Cambridge, MA 02142, USA.
Adrianna K San RomanWhitehead Institute, Cambridge, MA 02142, USA.
Geryl WoodInflammatory Disease Section, Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Ashley BuscettaMedical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Nicole BanksMedical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA; Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Helen SkaletskyWhitehead Institute, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Whitehead Institute, Cambridge, MA 02142, USA.
Alexander K GodfreyWhitehead Institute, Cambridge, MA 02142, USA.
Thao T PhamWhitehead Institute, Cambridge, MA 02142, USA.
Jennifer F HughesWhitehead Institute, Cambridge, MA 02142, USA.
Laura G BrownWhitehead Institute, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Whitehead Institute, Cambridge, MA 02142, USA.
Paul KruszkaMedical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Angela E LinGenetics Unit, MassGeneral for Children, Boston, MA 02114, USA.
Daniel L KastnerInflammatory Disease Section, Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Maximilian MuenkeMedical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
David C PageWhitehead Institute, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Whitehead Institute, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: dcpage@wi.mit.edu.

Funding

Genetic Analysis of Complex Inflammatory DisordersZIAHG200371 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI KASTNER, DANIEL · 2011 to 2024
$18.8M
Beyond the reproductive tract: The future of Y chromosome researchU01HG007587 · NHGRI · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI MUENKE, MAXIMILIAN, PAGE, DAVID C. · 2015 to 2017
$1.4M
Effects of sex chromosome constitution on global gene expressionF32HD091966 · NICHD · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI SAN ROMAN, ADRIANNA K · 2017 to 2020
$224k
NHGRI NIH HHS U01 HG007587NICHD NIH HHS F32 HD091966
6 · The paper itself

Abstract

Recent in vitro studies of human sex chromosome aneuploidy showed that the Xi ("inactive" X) and Y chromosomes broadly modulate autosomal and Xa ("active" X) gene expression. We tested these findings in vivo. Linear modeling of CD4

Indexed as

Chromosomes, Human, YTranscriptomeCD4-Positive T-LymphocytesChromosomes, Human, XFemaleHumansMaleMonocytesaneuploidyCD4(+) T cell activationgene expressionlinear modelingprimary CD4(+) T cellsprimary monocytessex chromosomessex differences

Identifiers

PMID39111319
PMCPMC11480847

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.