Evidence map›Paper›PMID 39111315›Full record

ArticleImmunity2024

The cytokine Meteorin-like inhibits anti-tumor CD8

Christopher M Jackson, Ayush Pant, Wikum Dinalankara, John Choi, Aanchal Jain, Ryan Nitta, Eli Yazigi, Laura Saleh, Liang Zhao, Thomas R Nirschl and 21 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Trial
  2. Mitochondrial dynamics and T cells immunity in cancer.Biochemistry and biophysics reports · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Metrnl in health and disease: tissue-specific actions and signaling networks.Apoptosis : an international journal on programmed cell death · 2026
    Review
  11. Article
  12. Metabolic Checkpoints in CD8International journal of biological sciences · 2026
    Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Translational cancer research · 2025
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Christopher M JacksonDepartment of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: cjacks53@jhmi.edu.
Ayush PantBloomberg-Kimmel Institute for Immunotherapy, Departments of Oncology and Medicine, and the Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Wikum DinalankaraBloomberg-Kimmel Institute for Immunotherapy, Departments of Oncology and Medicine, and the Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
John ChoiDepartment of Neurosurgery, Stanford School of Medicine, Palo Alto, CA, USA.
Aanchal JainDepartment of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Ryan NittaDepartment of Neurosurgery, Stanford School of Medicine, Palo Alto, CA, USA.
Eli YazigiDepartment of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Laura SalehDepartment of Neurosurgery, Stanford School of Medicine, Palo Alto, CA, USA.
Liang ZhaoBloomberg-Kimmel Institute for Immunotherapy, Departments of Oncology and Medicine, and the Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Thomas R NirschlBloomberg-Kimmel Institute for Immunotherapy, Departments of Oncology and Medicine, and the Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Christina M KochelBloomberg-Kimmel Institute for Immunotherapy, Departments of Oncology and Medicine, and the Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Brandon Hwa-Lin BergsneiderDepartment of Neurosurgery, Stanford School of Medicine, Palo Alto, CA, USA.
Denis RoutkevitchDepartment of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Kisha PatelDepartment of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Kwang Bog ChoDepartment of Neurosurgery, Stanford School of Medicine, Palo Alto, CA, USA.
Stephany TzengBiomedical Engineering Department, Johns Hopkins University, Baltimore, MD, USA.
Sarah Y NeshatBiomedical Engineering Department, Johns Hopkins University, Baltimore, MD, USA.
Young-Hoon KimDepartment of Neurosurgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Barbara J SmithDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Maria Cecilia RamelloCenter for Cell Therapy, Stanford Cancer Institute, Stanford School of Medicine, Stanford, CA, USA.
Elena SotilloCenter for Cell Therapy, Stanford Cancer Institute, Stanford School of Medicine, Stanford, CA, USA.
Xinnan WangDepartment of Neurosurgery, Stanford School of Medicine, Palo Alto, CA, USA.
Jordan J GreenBiomedical Engineering Department, Johns Hopkins University, Baltimore, MD, USA.
Chetan BettegowdaDepartment of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Gordon LiDepartment of Neurosurgery, Stanford School of Medicine, Palo Alto, CA, USA.
Henry BremDepartment of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Crystal L MackallCenter for Cell Therapy, Stanford Cancer Institute, Stanford School of Medicine, Stanford, CA, USA; Department of Pediatrics, Stanford School of Medicine, Stanford, CA, USA; Department of Medicine, Stanford School of Medicine, Stanford, CA, USA.
Drew M PardollBloomberg-Kimmel Institute for Immunotherapy, Departments of Oncology and Medicine, and the Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Charles G DrakeBloomberg-Kimmel Institute for Immunotherapy, Departments of Oncology and Medicine, and the Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Luigi MarchionniBloomberg-Kimmel Institute for Immunotherapy, Departments of Oncology and Medicine, and the Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Michael LimDepartment of Neurosurgery, Stanford School of Medicine, Palo Alto, CA, USA. Electronic address: mklim@stanford.edu.

Funding

Hardwiring Mechanism into Predicting Cancer Phenotypes by Computational LearningR01CA200859 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI MARCHIONNI, LUIGI · 2016 to 2020
$1.9M
NCI NIH HHS R01 CA200859
6 · The paper itself

Abstract

Tumor-infiltrating lymphocyte (TIL) hypofunction contributes to the progression of advanced cancers and is a frequent target of immunotherapy. Emerging evidence indicates that metabolic insufficiency drives T cell hypofunction during tonic stimulation, but the signals that initiate metabolic reprogramming in this context are largely unknown. Here, we found that Meteorin-like (METRNL), a metabolically active cytokine secreted by immune cells in the tumor microenvironment (TME), induced bioenergetic failure of CD8

Indexed as

CD8-Positive T-LymphocytesLymphocytes, Tumor-InfiltratingMitochondriaTumor MicroenvironmentAnimalsCell Line, TumorCytokinesEnergy MetabolismGlycolysisHumansMiceMice, Inbred C57BLMice, KnockoutNeoplasmsOxidative PhosphorylationPPAR deltaCytokinesPPAR deltaanti-tumor immunityCD8(+) T cell hypofunctionMeteorin-like proteinmitochondrial dysfunctionT cell exhaustion

Identifiers

PMID39111315
PMCPMC11324406

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.