ArticleCell metabolism2024
Intermittent clearance of p21-highly-expressing cells extends lifespan and confers sustained benefits to health and physical function.
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Article in Cell metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38citing papers in PubMed
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Who cites it
38 citing papers in PubMed.
- A self-assembled Dendrobium polysaccharide hydrogel with anti-aging activity via the FOXO signaling pathway.Natural products and bioprospecting · 2026Article
- Senolytics dasatinib and quercetin in metabolic dysfunction-associated steatohepatitis: a proof-of-principle randomized, controlled trial.Nature metabolism · 2026Article
- Methylation-associated Gene Expression (MaGE): a non-invasive, in vivo measure of cellular senescence.medRxiv : the preprint server for health sciences · 2026Article
- Review
- From aging biology to cardiac biotechnology: emerging platforms for modeling cardiac aging.JCI insight · 2026Review
- Fueling the fire: metabolic dysfunction and senescence as drivers of lung aging and disease.Physiological reviews · 2026Review
- T cell senescence induced by DNMT1 deletion mediates cardiac transplant tolerance via altered CDKN1A methylation.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- Profiling the molecular and physiological effects of senolytic treatment on aged mice identifies immune, fibrotic and metabolic remodeling.Nature aging · 2026Article
- Article
- Senescent cells in systemic aging: SASP heterogeneity, immune escape, and endocrine modulation.Biogerontology · 2026Review
- T Cell Immunosenescence in Inflammatory Skin Diseases: Pathogenesis and Therapeutic Targets.Aging cell · 2026Review
- CHK2-USP37 axis stabilizes FOXO4 to sustain senescence and evade apoptosis.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Fluorescence-Guided Spatial Mapping of p21-Expressing Senescent Cells in Aged Liver at Single-Cell Resolution.Biomolecules · 2026Article
- p21Nature aging · 2026Article
- Redefining senescence through hepatocyte fate changes in liver diseases.Trends in endocrinology and metabolism: TEM · 2026Review
- Necroptosis induced by MLKL overexpression in liver triggers cellular senescence and leads to chronic inflammation and fibrosis.GeroScience · 2026Article
- The p21 resilience network: a conceptual framework linking senescence to ferroptosis and cuproptosis resistance.NPJ systems biology and applications · 2026Review
- Adipocytes as core drivers of skin aging and novel targets for regeneration.Biogerontology · 2026Review
- Cellular sensor DAP5 decodesFrontiers in immunology · 2026Article
- Cellular senescence in musculoskeletal diseases: biological mechanisms and clinical implications.Theranostics · 2026Review
Corrections and comments
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Authors and funding
26 authors.
Binsheng WangUConn Center on Aging, UConn Health, Farmington, CT 06030, USA; Department of Genetics and Genome Sciences, UConn Health, Farmington, CT 06030, USA.
Lichao WangUConn Center on Aging, UConn Health, Farmington, CT 06030, USA; Department of Genetics and Genome Sciences, UConn Health, Farmington, CT 06030, USA.
Nathan S GasekUConn Center on Aging, UConn Health, Farmington, CT 06030, USA; Department of Genetics and Genome Sciences, UConn Health, Farmington, CT 06030, USA.
Chia-Ling KuoUConn Center on Aging, UConn Health, Farmington, CT 06030, USA; Department of Public Health Sciences, UConn Health, Farmington, CT 06030, USA.
Jia NieDivision of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Taewan KimUConn Center on Aging, UConn Health, Farmington, CT 06030, USA; Department of Genetics and Genome Sciences, UConn Health, Farmington, CT 06030, USA.
Pengyi YanUConn Center on Aging, UConn Health, Farmington, CT 06030, USA; Department of Genetics and Genome Sciences, UConn Health, Farmington, CT 06030, USA.
Junyu ZhuUConn Center on Aging, UConn Health, Farmington, CT 06030, USA; Department of Genetics and Genome Sciences, UConn Health, Farmington, CT 06030, USA.
Blake L TorranceUConn Center on Aging, UConn Health, Farmington, CT 06030, USA; Department of Immunology, UConn Health, Farmington, CT 06030, USA.
Yueying ZhouUConn Center on Aging, UConn Health, Farmington, CT 06030, USA; Xiangya Stomatological Hospital, Central South University, Changsha, China.
Lisa C FloresSam and Ann Barshop Institute for Longevity and Aging Studies and Department of Pathology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Colton AllenSam and Ann Barshop Institute for Longevity and Aging Studies and Department of Pathology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Allison M AndradeUConn Center on Aging, UConn Health, Farmington, CT 06030, USA.
Chun GuoUConn Center on Aging, UConn Health, Farmington, CT 06030, USA.
Rachel L CohnUConn Center on Aging, UConn Health, Farmington, CT 06030, USA; Department of Genetics and Genome Sciences, UConn Health, Farmington, CT 06030, USA.
Evan R JellisonDepartment of Immunology, UConn Health, Farmington, CT 06030, USA.
Jenna M BartleyUConn Center on Aging, UConn Health, Farmington, CT 06030, USA; Department of Immunology, UConn Health, Farmington, CT 06030, USA.
George A KuchelUConn Center on Aging, UConn Health, Farmington, CT 06030, USA.
Sheng LiThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06030, USA.
Tamar PirtskhalavaDivision of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Center for Advanced Gerotherapeutics, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Tamar TchkoniaDivision of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Center for Advanced Gerotherapeutics, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Sumit YadavDepartment of Growth and Development, UNMC College of Dentistry, Omaha, NE 68114, USA; Children's of Omaha - Children's Hospital, Omaha, NE 68114, USA.
Laura HaynesUConn Center on Aging, UConn Health, Farmington, CT 06030, USA; Department of Immunology, UConn Health, Farmington, CT 06030, USA.
James L KirklandDivision of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Center for Advanced Gerotherapeutics, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Division of General Internal Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Yuji IkenoSam and Ann Barshop Institute for Longevity and Aging Studies and Department of Pathology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA; Geriatric Research Education and Clinical Center (GRECC), Audie L. Murphy VA Hospital, South Texas Veterans Health Care System, San Antonio, TX 78229, USA.
Ming XuUConn Center on Aging, UConn Health, Farmington, CT 06030, USA; Department of Genetics and Genome Sciences, UConn Health, Farmington, CT 06030, USA. Electronic address: mixu@uchc.edu.
Funding
Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI William Carl Skarnes · 1985 to 2026
$61.9MTRANSGENIC COREP30AG013319 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI PETER J HORNSBY · 1995 to 2026
$30.6MTargeting Cellular Senescence to Extend HealthspanP01AG062413 · NIA · MAYO CLINIC ROCHESTER · PI Sundeep Khosla · 2019 to 2026
$28.7MSan Antonio OAIC - Research Education Component (REC)P30AG044271 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Adam Salmon, Elena Volpi · 2015 to 2026
$14.1MThe Jackson Laboratory Senescence Tissue Mapping Center (JAX-Sen TMC) - Data Analysis CoreU54AG079753 · NIA · JACKSON LABORATORY · PI ROSENTHAL, NADIA A · 2022 to 2025
$11.0MResearch Education ComponentP30AG067988 · NIA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Richard H Fortinsky, GEORGE A KUCHEL · 2021 to 2026
$9.5MEffect of Aging on Preadipocyte DifferentiationR37AG013925 · NIA · MAYO CLINIC ROCHESTER · PI KIRKLAND, JAMES L. · 2016 to 2025
$6.6MTranslational Geroscience NetworkR33AG061456 · NIA · MAYO CLINIC ROCHESTER · PI JAMES L. KIRKLAND, STEPHEN B. KRITCHEVSKY · 2019 to 2026
$6.2MSan Diego Nathan Shock CenterP30AG068635 · NIA · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI SHADEL, GERALD · 2020 to 2024
$6.0MReciprocal Modulation of the Microbiome and Cellular Senescence in Metabolic DysfunctionR01AG068860 · NIA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI XU, MING, ZHOU, YANJIAO · 2020 to 2024
$2.8MTargeting p21-Highly Expressing Cells to Increase Lifespan and Healthspan in Old AgeR01AG076642 · NIA · UNIVERSITY OF MINNESOTA · PI Ming Xu · 2022 to 2026
$2.4MTargeting p21-positive Senescent Cells in vivo for Alleviating Metabolic and Physical DysfunctionR01AG066679 · NIA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI XU, MING · 2020 to 2024
$2.2MNCI NIH HHS P30 CA034196NHGRI NIH HHS T32 HG010463NIA NIH HHS F30 AG081092NIA NIH HHS P01 AG062413NIA NIH HHS P30 AG013319NIA NIH HHS P30 AG044271NIA NIH HHS P30 AG067988NIA NIH HHS P30 AG068635NIA NIH HHS R01 AG066679NIA NIH HHS R01 AG068860NIA NIH HHS R01 AG076642NIA NIH HHS R03 AG072374NIA NIH HHS R21 AG071292NIA NIH HHS R33 AG061456NIA NIH HHS R37 AG013925NIA NIH HHS U54 AG079753
Abstract
A key challenge in aging research is extending lifespan in tandem with slowing down functional decline so that life with good health (healthspan) can be extended. Here, we show that monthly clearance, starting from 20 months, of a small number of cells that highly express p21
Indexed as
Cyclin-Dependent Kinase Inhibitor p21LongevityMice, Inbred C57BLAgingAnimalsFemaleMaleMiceCdkn1a protein, mouseCyclin-Dependent Kinase Inhibitor p21agingcellular senescencefrailtyinflammationmorbidity compression
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.