Evidence map›Paper›PMID 39111091›Full record

ArticleJournal of colloid and interface science2025

New experiments and models to describe soluble surfactant adsorption above and below the critical micelle concentration.

Boxun Huang, Steven V Iasella, Meenal Rathi, Joseph Hassler, Clara O Ciutara, Ziwen He, David C Morse, Joseph A Zasadzinski

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of colloid and interface science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Boxun HuangDepartment of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, USA.
Steven V IasellaDepartment of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, USA.
Meenal RathiDepartment of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, USA.
Joseph HasslerDepartment of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, USA.
Clara O CiutaraDepartment of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, USA.
Ziwen HeDepartment of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, USA.
David C MorseDepartment of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: morse012@umn.edu.
Joseph A ZasadzinskiDepartment of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: zasad008@umn.edu.

Funding

LIPID AND PROTEIN EFFECTS ON MONOLAYER STABILITYR01HL051177 · NHLBI · UNIVERSITY OF MINNESOTA · PI Joseph Anthony Zasadzinski · 1994 to 2026
$9.5M
Enhancing Adsorption of Lung Surfactants at the Air-Water Interface Using Methods from Colloid Stability TheoryF32HL151128 · NHLBI · UNIVERSITY OF MINNESOTA · PI IASELLA, STEVEN · 2020 to 2023
$248k
NHLBI NIH HHS F32 HL151128NHLBI NIH HHS R01 HL051177
6 · The paper itself

Abstract

hypothesisLysopalmitoylphosphatidylcholine (LysoPC) is a soluble single-chain surfactant product of the innate immune system degradation of double-chain phospholipids. LysoPC adsorption to the air-water interface in lung alveoli can be modeled using alveolar-sized bubbles of constant surface area in a capillary pressure microtensiometer to show that adsorption is diffusion limited both below and above the critical micelle concentration (CMC). Above the CMC, a local equilibrium model is proposed in which depletion of the local monomer concentration drives dissociation of micelles in a region near the bubble surface. EXPERIMENTAL: A capillary pressure microtensiometer in which a feedback loop maintains a constant bubble radius and surface area is used to measure dynamic surface tension during LysoPC adsorption. Direct numerical solution of the spherical diffusion equations, a new three parameter virial equation of state for interface thermodynamics, and a local equilibrium model of micellization above the CMC are used to accurately model the dynamic surface tension experiments both below and above the LysoPC CMC.

findingsLysoPC adsorption is shown to be diffusion-limited over concentrations ranging from below to well above the CMC, and to be well described by a local equilibrium model at concentrations above the CMC. Modelling the dynamic surface tension provides a reliable estimate of the micelle diffusivity near the CMC that is difficult to obtain by other methods in systems with low CMCs.

Identifiers

PMID39111091
PMCPMC11461105

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.