Evidence map›Paper›PMID 39110808›Full record

ArticleScience advances2024

Acousto-dielectric tweezers enable independent manipulation of multiple particles.

Liang Shen, Zhenhua Tian, Kaichun Yang, Joseph Rich, Jinxin Zhang, Jianping Xia, Wesley Collyer, Brandon Lu, Nanjing Hao, Zhichao Pei and 2 more

Abstract read
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Metamaterials and Fluid Flows.Nature communications · 2026
    Review
  4. Article
  5. Article
  6. Acoustic Rising Microbubbles for Efficient Liquid Operations.Cyborg and bionic systems (Washington, D.C.) · 2026
    Article
  7. Article
  8. Review
  9. Isolation Techniques of Micro/Nano-Scaled Species for Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Liang ShenDepartment of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA.ORCID 0000-0002-5415-8394
Zhenhua TianDepartment of Mechanical Engineering, Virginia Polytechnical Institute and State University, Blacksburg, VA 24061, USA.ORCID 0000-0002-1903-5604
Kaichun YangDepartment of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA.
Joseph RichDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.ORCID 0000-0002-6249-2093
Jinxin ZhangDepartment of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA.ORCID 0000-0001-6492-8519
Jianping XiaDepartment of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA.ORCID 0000-0001-9902-0228
Wesley CollyerDepartment of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA.
Brandon LuDepartment of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA.ORCID 0009-0003-6438-4074
Nanjing HaoDepartment of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA.ORCID 0000-0003-3808-7941
Zhichao PeiDepartment of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA.
Chuyi ChenDepartment of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA.ORCID 0000-0001-5733-4261
Tony Jun HuangDepartment of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA.ORCID 0000-0003-1205-3313

Funding

Development of a multifunctional, acoustofluidic 3D bioprinter with single-cell resolutionR01GM144417 · NIGMS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI Zhenhua Tian · 2022 to 2026
$1.8M
NIGMS NIH HHS R01 GM144417
6 · The paper itself

Abstract

Acoustic tweezers have gained substantial interest in biology, engineering, and materials science for their label-free, precise, contactless, and programmable manipulation of small objects. However, acoustic tweezers cannot independently manipulate multiple microparticles simultaneously. This study introduces acousto-dielectric tweezers capable of independently manipulating multiple microparticles and precise control over intercellular distances and cyclical cell pairing and separation for detailed cell-cell interaction analysis. Our acousto-dielectric tweezers leverage the competition between acoustic radiation forces, generated by standing surface acoustic waves (SAWs), and dielectrophoretic (DEP) forces, induced by gradient electric fields. Modulating these fields allows for the precise positioning of individual microparticles at points where acoustic radiation and DEP forces are in equilibrium. This mechanism enables the simultaneous movement of multiple microparticles along specified paths as well as cyclical cell pairing and separation. We anticipate our acousto-dielectric tweezers to have enormous potential in colloidal assembly, cell-cell interaction studies, disease diagnostics, and tissue engineering.

Indexed as

Optical TweezersAcousticsHumans

Identifiers

PMID39110808
PMCPMC11305384

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.