ArticleScience advances2024
KAT2A and KAT2B prevent double-stranded RNA accumulation and interferon signaling to maintain intestinal stem cell renewal.
Abstract read
In one paragraph
Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- A spatial and temporal transcriptomic atlas of mouse intestinal regeneration in the jejunum.Nature communications · 2026Article
- Post-translational modifications in metabolic reprogramming: implications for metabolic therapy and immunotherapy in cancer.Signal transduction and targeted therapy · 2026Review
- Article
- Cell-specific multi-target mechanisms of cotinine in cervical cancer oncogenesis and progression.Discover oncology · 2026Article
- NAT10/acProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Disruption of the SAGA CORE triggers collateral degradation of KAT2A.Nature communications · 2026Article
- Streptococcus suis disrupts the blood-brain barrier through inducing ubiquitin-proteasome-mediated degradation of KAT2A.Veterinary research · 2026Article
- HAT1 Regulates Intestinal Stem Cell Proliferation and Differentiation.bioRxiv : the preprint server for biology · 2026Article
- In vivo CRISPR screening identifies SAGA complex members as key regulators of hematopoiesis.Nature communications · 2026Article
- Synergistic anticancer effects of cabozantinib and cuproptosis induction driven by DHRS2-KAT2A-H3K27ac axis in clear cell renal cell carcinoma.Biology direct · 2026Article
- Destabilization of cardiac myosin acetylation and sequestration with type 2 diabetes mellitus.Cardiovascular diabetology · 2026Article
- Knockdown of USP22 alleviates LPS-induced microglial inflammation and mouse depressive-like behaviors via KAT2A.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Epigenetic regulation of cancer stemness.Signal transduction and targeted therapy · 2025Review
- Acetyltransferase in cardiovascular disease and aging.The journal of cardiovascular aging · 2024Article
Corrections and comments
- Update of
Authors and funding
18 authors.
Mai-Uyen NguyenDepartment of Genetics, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.ORCID 0000-0003-0936-2019
Jahangir IqbalDepartment of Genetics, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.ORCID 0000-0002-9021-2271
Sarah PotgieterDepartment of Animal Sciences, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.ORCID 0000-0002-1117-2612
Winston HuangDepartment of Genetics, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.ORCID 0009-0009-6289-3928
Julie PfefferDepartment of Genetics, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.ORCID 0009-0004-4753-017X
Sean WooDepartment of Genetics, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.ORCID 0009-0002-0108-1714
Caifeng ZhaoCenter for Advanced Biotechnology and Medicine, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.ORCID 0000-0002-9957-1406
Matthew LawlorDepartment of Genetics, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.ORCID 0000-0003-0700-5763
Richard YangDepartment of Genetics, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
Rahma RizlyDepartment of Genetics, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.ORCID 0009-0003-1922-2199
Angela HalsteadDivision of Gastroenterology, Departments of Medicine and Molecular Cell Biology, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0000-0003-4892-0642
Sharon DentThe University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-4824-3269
José B SáenzDivision of Gastroenterology, Departments of Medicine and Molecular Cell Biology, Washington University in St. Louis, St. Louis, MO, USA.
Haiyan ZhengCenter for Advanced Biotechnology and Medicine, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
Zuo-Fei YuanSt. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0003-1252-6766
Simone SidoliAlbert Einstein College of Medicine, The Bronx, NY, USA.ORCID 0000-0001-9073-6641
Christopher E EllisonDepartment of Genetics, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.ORCID 0000-0002-0350-0962
Michael P VerziDepartment of Genetics, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.ORCID 0000-0003-4082-4330
Funding
TRANSCRIPTIONAL PROFILINGP30CA072720 · NCI · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI Tracie Saunders · 1997 to 2026
$94.5MMechanisms Driving Metabolic Shifts in the Intestinal EpitheliumR01DK126446 · NIDDK · RUTGERS, THE STATE UNIV OF N.J. · PI VERZI, MICHAEL P. · 2021 to 2025
$2.1MGenetic and Molecular Definition of Histone Modifying Enzyme FunctionsR35GM131678 · NIGMS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DENT, SHARON Y. R. · 2019 to 2023
$2.0MMechanisms of Intestinal Epithelial DifferentiationR01DK121915 · NIDDK · RUTGERS, THE STATE UNIV OF N.J. · PI ELLISON, CHRISTOPHER EUGENE, VERZI, MICHAEL P. · 2020 to 2023
$1.7MAn Orbitrap Tribrid mass spectrometer and nanoflow LC system to upgrade the proteomics facility at Rutgers-New Brunswick and Robert Wood Johnson Medical SchoolS10OD025140 · OD · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI LOBEL, PETER · 2019 to 2019
$921kFunctions of KAT2A and KAT2B in intestinal homeostasis and colon cancer.F31CA254086 · NCI · RUTGERS, THE STATE UNIV OF N.J. · PI NGUYEN, MAI UYEN · 2020 to 2022
$126kNCI NIH HHS F31 CA254086NCI NIH HHS P30 CA072720NIDDK NIH HHS R01 DK121915NIDDK NIH HHS R01 DK126446NIGMS NIH HHS R35 GM131678NIH HHS S10 OD025140
Abstract
Histone acetyltransferases
Indexed as
Histone AcetyltransferasesInterferonsMice, KnockoutRNA, Double-StrandedSignal TransductionStem CellsAnimalsCell Self RenewalIntestinal MucosaIntestinesMiceMitochondriaHistone AcetyltransferasesInterferonsRNA, Double-Stranded
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.