ArticlePLoS biology2024
Comprehensive blueprint of Salmonella genomic plasticity identifies hotspots for pathogenicity genes.
Article in PLoS biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Genomic islands in Wolbachia prophages drive amplification and diversification of cytoplasmic incompatibility genes in Culex pipiens.Genetics · 2026Article
- Review
- Bacteriophages mobilize bacterial defense systems via lateral transduction.Science advances · 2026Article
- Genomic islands inNAR genomics and bioinformatics · 2025Article
- Genomic insights into multidrug resistant Escherichia coli from bovine mastitis in Bangladesh.BMC microbiology · 2025Article
- Characteristics of phage-plasmids and their impact on microbial communities.Essays in biochemistry · 2024Review
- An exploration of unusual antimicrobial resistance phenotypes in Salmonella Typhi from Blantyre, Malawi reveals the ongoing role of IncHI1 plasmids.Gates open research · 2024Article
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Authors and funding
8 authors.
Funding
Abstract
Understanding the dynamic evolution of Salmonella is vital for effective bacterial infection management. This study explores the role of the flexible genome, organised in regions of genomic plasticity (RGP), in shaping the pathogenicity of Salmonella lineages. Through comprehensive genomic analysis of 12,244 Salmonella spp. genomes covering 2 species, 6 subspecies, and 46 serovars, we uncover distinct integration patterns of pathogenicity-related gene clusters into RGP, challenging traditional views of gene distribution. These RGP exhibit distinct preferences for specific genomic spots, and the presence or absence of such spots across Salmonella lineages profoundly shapes strain pathogenicity. RGP preferences are guided by conserved flanking genes surrounding integration spots, implicating their involvement in regulatory networks and functional synergies with integrated gene clusters. Additionally, we emphasise the multifaceted contributions of plasmids and prophages to the pathogenicity of diverse Salmonella lineages. Overall, this study provides a comprehensive blueprint of the pathogenicity potential of Salmonella. This unique insight identifies genomic spots in nonpathogenic lineages that hold the potential for harbouring pathogenicity genes, providing a foundation for predicting future adaptations and developing targeted strategies against emerging human pathogenic strains.
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Registered trials
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