Evidence map›Paper›PMID 39110589›Full record

ArticleCell reports2024

Regulation of MYC by CARD14 in human epithelium is a determinant of epidermal homeostasis and disease.

Stanley B DeVore, Matthew Schuetz, Lauren Alvey, Henry Lujan, David E Ochayon, Lindsey Williams, Wan Chi Chang, Alyssa Filuta, Brandy Ruff, Arjun Kothari and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Protective and Reparative Effects ofJournal of microbiology and biotechnology · 2025
    Article
  2. Update on the genetics of allergic diseases.The Journal of allergy and clinical immunology · 2025
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Stanley B DeVoreDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA; Division of Asthma Research, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA; Division of Human Genetics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Matthew SchuetzDivision of Asthma Research, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Lauren AlveyDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Henry LujanDivision of Asthma Research, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
David E OchayonDivision of Asthma Research, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Lindsey WilliamsDivision of Asthma Research, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Wan Chi ChangDivision of Asthma Research, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Alyssa FilutaDivision of Asthma Research, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Brandy RuffDivision of Asthma Research, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Arjun KothariDivision of Asthma Research, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Jennifer M HahnDepartment of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Eric BrandtDivision of Asthma Research, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Latha SatishDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA; Division of Asthma Research, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Krishna RoskinDivision of Biomedical Informatics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Andrew B HerrDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA; Division of Immunobiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Jocelyn M BiaginiDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA; Division of Asthma Research, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Lisa J MartinDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA; Division of Asthma Research, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA; Division of Biostatistics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Deniz CagdasDivision of Pediatric Immunology, Department of Pediatrics, Hacettepe University Medical School, Ihsan Dogramaci Children's Hospital, Institutes of Child Health, Ankara 06230, Turkey.
Sevgi KelesDivision of Pediatric Immunology and Allergy, Necmettin Erbakan University, Konya 42090, Turkey.
Joshua D MilnerDepartment of Pediatrics, Columbia University, New York, NY 10027, USA.
Dorothy M SuppDepartment of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA; Scientific Staff, Shriners Children's Ohio, Dayton, OH 45404, USA.
Gurjit K Khurana HersheyDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA; Division of Asthma Research, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA. Electronic address: gurjit.hershey@cchmc.org.

Funding

TSLP, IL-9-producing mucosal mast cells, and allergic inflammationU19AI070235 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI Gurjit K. Khurana Hershey · 2006 to 2026
$31.3M
Molecular Epidemiology in Children's Environmental Health Training Program (MECEH)T32ES010957 · NIEHS · UNIVERSITY OF CINCINNATI · PI Kelly J Brunst · 2001 to 2026
$11.1M
Medical Scientist Training ProgramT32GM063483 · NIGMS · UNIVERSITY OF CINCINNATI · PI KHURANA HERSHEY, GURJIT K. · 2002 to 2022
$6.7M
Mechanisms of staphylococcal skin colonizationR01AI162964 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI PAUL D FEY, ANDREW B HERR · 2022 to 2026
$2.4M
NIAID NIH HHS R01 AI162964NIAID NIH HHS U19 AI070235NIEHS NIH HHS T32 ES010957NIGMS NIH HHS T32 GM063483
6 · The paper itself

Abstract

Caspase recruitment domain family member 14 (CARD14) and its variants are associated with both atopic dermatitis (AD) and psoriasis, but their mechanistic impact on skin barrier homeostasis is largely unknown. CARD14 is known to signal via NF-κB; however, CARD14-NF-κB signaling does not fully explain the heterogeneity of CARD14-driven disease. Here, we describe a direct interaction between CARD14 and MYC and show that CARD14 signals through MYC in keratinocytes to coordinate skin barrier homeostasis. CARD14 directly binds MYC and influences barrier formation in an MYC-dependent fashion, and this mechanism is undermined by disease-associated CARD14 variants. These studies establish a paradigm that CARD14 activation regulates skin barrier function by two distinct mechanisms, including activating NF-κB to bolster the antimicrobial (chemical) barrier and stimulating MYC to bolster the physical barrier. Finally, we show that CARD14-dependent MYC signaling occurs in other epithelia, expanding the impact of our findings beyond the skin.

Indexed as

CARD Signaling Adaptor ProteinsEpidermisHomeostasisKeratinocytesNF-kappa BProto-Oncogene Proteins c-mycDermatitis, AtopicEpitheliumGuanylate CyclaseHumansMembrane ProteinsProtein BindingPsoriasisSignal TransductionCARD14 protein, humanCARD Signaling Adaptor ProteinsGuanylate CyclaseMembrane ProteinsMYC protein, humanNF-kappa BProto-Oncogene Proteins c-mycallergic diseaseatopic dermatitisatopybarrier homeostasisCARD14CP: Developmental biologyepidermisepitheliumkeratinocyteMYCskin barrier

Identifiers

PMID39110589
PMCPMC11469028

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.