Evidence map›Paper›PMID 39110529›Full record

ArticleMolecular biology of the cell2024

Dimerization activates the Inversin complex in

Erika Beyrent, Derek T Wei, Gwendolyn M Beacham, Sangwoo Park, Jian Zheng, Matthew J Paszek, Gunther Hollopeter

Abstract read
In one paragraph

Article in Molecular biology of the cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Erika BeyrentDepartment of Molecular Medicine, Cornell University, Ithaca, NY 14853.
Derek T WeiDepartment of Molecular Medicine, Cornell University, Ithaca, NY 14853.
Gwendolyn M BeachamDepartment of Molecular Medicine, Cornell University, Ithaca, NY 14853.
Sangwoo ParkField of Biophysics, Cornell University, Ithaca, NY 14853.
Jian ZhengDepartment of Molecular Medicine, Cornell University, Ithaca, NY 14853.
Matthew J PaszekField of Biophysics, Cornell University, Ithaca, NY 14853.
Gunther HollopeterDepartment of Molecular Medicine, Cornell University, Ithaca, NY 14853.ORCID 0000-0002-6409-0530

Funding

Molecular regulation of the AP2 clathrin adaptor complexR01GM127548 · NIGMS · CORNELL UNIVERSITY · PI HOLLOPETER, GUNTHER · 2019 to 2023
$2.1M
Acquisition of an automated phase and fluorescence microscope for Cornell BRC Imaging FacilityS10OD032251 · OD · CORNELL UNIVERSITY · PI WILLIAMS, REBECCA M · 2022 to 2022
$229k
NIGMS NIH HHS R01 GM127548NIH HHS S10 OD032251
6 · The paper itself

Abstract

Genetic, colocalization, and biochemical studies suggest that the ankyrin repeat-containing proteins Inversin (INVS) and ANKS6 function with the NEK8 kinase to control tissue patterning and maintain organ physiology. It is unknown whether these three proteins assemble into a static "Inversin complex" or one that adopts multiple bioactive forms. Through the characterization of hyperactive alleles in

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsAnimalsAnkyrin RepeatDimerizationOptogeneticsPhenotypeProtein MultimerizationProtein Serine-Threonine KinasesCaenorhabditis elegans ProteinsProtein Serine-Threonine Kinases

Identifiers

PMID39110529
PMCPMC11481705

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.