Article in Journal of neurophysiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
14 authors.
Emily LecyDepartment of Neuroscience, University of Minnesota, Minneapolis, Minnesota, United States.ORCID 0000-0002-1410-616X
Maria E Linn-EvansDepartment of Neuroscience, University of Minnesota, Minneapolis, Minnesota, United States.ORCID 0000-0002-8535-2894
Sommer L Amundsen-HuffmasterDepartment of Neurology, University of Minnesota, Minneapolis, Minnesota, United States.ORCID 0000-0001-8079-328X
Tara PalnitkarCenter for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota, United States.
Remi PatriatCenter for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota, United States.ORCID 0000-0003-2928-3772
Jae Woo ChungDepartment of Neurology, University of Minnesota, Minneapolis, Minnesota, United States.ORCID 0000-0002-9107-9038
Angela M NoeckerDepartment of Biomedical Engineering, Duke University, Durham, North Carolina, United States.ORCID 0000-0001-5833-4263
Michael C ParkDepartment of Neurology, University of Minnesota, Minneapolis, Minnesota, United States.ORCID 0000-0002-5680-0811
Cameron C McIntyreDepartment of Biomedical Engineering, Duke University, Durham, North Carolina, United States.ORCID 0000-0003-0932-854X
Jerrold L VitekDepartment of Neurology, University of Minnesota, Minneapolis, Minnesota, United States.ORCID 0000-0002-2308-6535
Scott E CooperDepartment of Neurology, University of Minnesota, Minneapolis, Minnesota, United States.
Noam HarelCenter for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota, United States.ORCID 0000-0002-6034-3801
Matthew D JohnsonDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota, United States.ORCID 0000-0001-9686-5540
Colum D MacKinnonDepartment of Neurology, University of Minnesota, Minneapolis, Minnesota, United States.ORCID 0000-0002-2722-7868
Funding
Understanding Circuit Dynamics in Parkinson's Disease using Real-Time Neural ControlP50NS123109 · NINDS · UNIVERSITY OF MINNESOTA · PI AMAN, JOSHUA E · 2021 to 2025
$11.3M
Pathophysiology-based approaches to deep brain stimulation for Parkinson's diseaseP50NS098573 · NINDS · UNIVERSITY OF MINNESOTA · PI VITEK, JERROLD L · 2016 to 2020
$9.1M
Targeted Pathway Activation for PosturalInstability and Gait Disorder in Parkinson'sDiseaseR01NS124814 · NINDS · UNIVERSITY OF MINNESOTA · PI SCOTT E COOPER · 2022 to 2026
$3.7M
Pathway targeted deep brain stimulation for Parkinson's diseaseR01NS085188 · NINDS · UNIVERSITY OF MINNESOTA · PI HAREL, NOAM, MCINTYRE, CAMERON · 2013 to 2017
$3.4M
7 Tesla Terra InstrumentS10OD025256 · OD · UNIVERSITY OF MINNESOTA · PI HAREL, NOAM · 2018 to 2018
$2.0M
EFFECTS OF DISEASE AND PALLIDAL DEEP BRAIN STIMULATION ON ANKLE MUSCLE CONTROL IN PARKINSON'S DISEASEF31HD112086 · NICHD · UNIVERSITY OF MINNESOTA · PI LECY, EMILY ELIZABETH · 2023 to 2024
$95k
HHS | National Institutes of Health (NIH) F31 HD112-86-01AHHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS124814HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) RO1 NS085188Minnesota Discovery Research Innovation Economy (MnDrive)Neurosciences Foundation (NSF) DGE-1734815NICHD NIH HHS F31 HD112086NIH HHS S10 OD025256NINDS NIH HHS P50 NS098573NINDS NIH HHS P50 NS123109NINDS NIH HHS R01 NS085188NINDS NIH HHS R01 NS124814ODCDC CDC HHS S10 OD025256
6 · The paper itself
Abstract
Deep brain stimulation (DBS) of the internal segment of the globus pallidus (GPi) can markedly reduce muscle rigidity in people with Parkinson's disease (PD); however, the mechanisms mediating this effect are poorly understood. Computational modeling of DBS provides a method to estimate the relative contributions of neural pathway activations to changes in outcomes. In this study, we generated subject-specific biophysical models of GPi DBS (derived from individual 7-T MRI), including pallidal efferent, putamenal efferent, and internal capsule pathways, to investigate how activation of neural pathways contributed to changes in forearm rigidity in PD. Ten individuals (17 arms) were tested off medication under four conditions: off stimulation, on clinically optimized stimulation, and on stimulation specifically targeting the dorsal GPi or ventral GPi. Quantitative measures of forearm rigidity, with and without a contralateral activation maneuver, were obtained with a robotic manipulandum. Clinically optimized GPi DBS settings significantly reduced forearm rigidity (
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Neural pathways associated with reduced rigidity during pallidal deep brain stimulation for Parkinson's disease. · full record | OpenQuestion