ArticleSurgery today2025
Prognostic factors for pediatric patients with severe intestinal motility disorders: a single institution's experience.
Article in Surgery today, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Congenital hypoganglionosis: phenotype-based outcomes and evolution of diagnosis and management-a systematic review.Pediatric surgery international · 2026Pooled it
- Decline in gut motility of cerebral palsy patients after a triggering event: A discussion on invasive versus conservative management.JPGN reports · 2025Article
- Temporary atypical vascular ultrasound-guided central venous approach in patients with venous occlusion.Surgery today · 2025Article
- Conditions that mimic Hirschsprung's disease, but that are not Hirschsprung's disease.World journal of pediatric surgery · 2025Review
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Authors and funding
19 authors.
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Abstract
purposeTo identify the prognostic factors for pediatric severe intestinal motility disorder (IMD).
methodsWe reviewed the medical records of patients with severe IMD, who required total parenteral nutrition (TPN) for ≥ 60 days at our institution between April, 1984 and March, 2023, examining their characteristics to identify prognostic factors.
resultsThe types of IMD in the 14 patients enrolled in this study were as follows: isolated hypoganglionosis (IHG, n = 6), extensive aganglionosis (EAG: n = 6), and chronic idiopathic intestinal pseudo-obstruction (CIIP, n = 2). There was no significant difference in mortality among the three types of severe IMD. Weaning-off TPN and the use of the colon were not significant prognostic factors, but cholestasis was a significant prognostic factor (p = 0.005). There was a high mortality rate (50%), with the major causes of death being intestinal failure-associated liver disease (IFALD) following hepatic failure, and catheter-related blood stream infection (CRBSI). One IHG patient underwent small bowel transplantation but died of acute rejection.
conclusionSevere IMD is still associated with a high mortality rate and cholestasis predicts the prognosis. Thus, preventing or improving IFALD and CRBSI caused by long-term TPN is important for reducing the mortality rate.
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