Evidence map›Paper›PMID 39110173›Full record

ArticleBasic research in cardiology2024

Deficiency of the sphingosine-1-phosphate (S1P) transporter Mfsd2b protects the heart against hypertension-induced cardiac remodeling by suppressing the L-type-Ca

Dragos Andrei Duse, Nathalie Hannelore Schröder, Tanu Srivastava, Marcel Benkhoff, Jens Vogt, Melissa Kim Nowak, Florian Funk, Nina Semleit, Philipp Wollnitzke, Ralf Erkens and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Basic research in cardiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Dragos Andrei DuseInstitute for Molecular Medicine III, University Hospital Düsseldorf and Heinrich Heine University, Düsseldorf, Germany.
Nathalie Hannelore SchröderInstitute for Molecular Medicine III, University Hospital Düsseldorf and Heinrich Heine University, Düsseldorf, Germany.
Tanu SrivastavaInstitute of Pharmacology, University Hospital Düsseldorf, Düsseldorf, Germany.
Marcel BenkhoffDepartment of Cardiology, Pneumology, and Vascular Medicine, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.
Jens VogtInstitute for Molecular Medicine III, University Hospital Düsseldorf and Heinrich Heine University, Düsseldorf, Germany.
Melissa Kim NowakInstitute for Molecular Medicine III, University Hospital Düsseldorf and Heinrich Heine University, Düsseldorf, Germany.
Florian FunkInstitute of Pharmacology, University Hospital Düsseldorf, Düsseldorf, Germany.
Nina SemleitInstitute for Molecular Medicine III, University Hospital Düsseldorf and Heinrich Heine University, Düsseldorf, Germany.
Philipp WollnitzkeInstitute for Molecular Medicine III, University Hospital Düsseldorf and Heinrich Heine University, Düsseldorf, Germany.
Ralf ErkensDepartment of Cardiology, Pneumology, and Vascular Medicine, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.
Sebastian KötterInstitute of Cardiovascular Physiology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Sven Günther MeuthDepartment of Neurology, Medical Faculty, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
Petra KeulInstitute for Molecular Medicine III, University Hospital Düsseldorf and Heinrich Heine University, Düsseldorf, Germany.
Webster SantosDepartment of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, VA, 24060, USA.
Amin PolzinDepartment of Cardiology, Pneumology, and Vascular Medicine, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.
Malte KelmDepartment of Cardiology, Pneumology, and Vascular Medicine, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.
Martina KrügerCardiovascular Research Institute Düsseldorf (CARID), Düsseldorf, Germany.
Joachim SchmittCardiovascular Research Institute Düsseldorf (CARID), Düsseldorf, Germany.
Bodo LevkauInstitute for Molecular Medicine III, University Hospital Düsseldorf and Heinrich Heine University, Düsseldorf, Germany. bodo.levkau@med.uni-duesseldorf.de.

Funding

Deutsche Forschungsgemeinschaft CRC 1116 GerokDeutsche Forschungsgemeinschaft LE 940/7-1Deutsche Forschungsgemeinschaft PO 2247/2-1Deutsche Forschungsgemeinschaft project B10Deutsche Forschungsgemeinschaft TRR259Medical Faculty of the Heinrich Heine University Clinician Scientist Track No. 2022-01
6 · The paper itself

Abstract

The erythrocyte S1P transporter Mfsd2b is also expressed in the heart. We hypothesized that S1P transport by Mfsd2b is involved in cardiac function. Hypertension-induced cardiac remodeling was induced by 4-weeks Angiotensin II (AngII) administration and assessed by echocardiography. Ca

Indexed as

Calcium Channels, L-TypeHypertensionLysophospholipidsMice, KnockoutMyocytes, CardiacSphingosineVentricular RemodelingAngiotensin IIAnimalsDisease Models, AnimalHumansMaleMiceMice, Inbred C57BLMyocardial ContractionProtein Phosphatase 2Angiotensin IICalcium Channels, L-TypeLysophospholipidsProtein Phosphatase 2Sphingosinesphingosine 1-phosphateCardioprotectionLeft-ventricular remodelingMfsd2bSphingosine-1-phosphate

Identifiers

PMID39110173
PMCPMC11461684

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.