Evidence map›Paper›PMID 39110115›Full record

ArticleInternational forum of allergy & rhinology2024

Nasal virus infection induces asthma exacerbation through B-cell-dependent recruitment of inflammatory monocytes.

Kody A Waldstein, Arman Issimov, Maria Ganama, Valerie Jinge, Stephen Tilley, Xiaoyang Hua

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International forum of allergy & rhinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Predictors of asthma exacerbations in children with or without house dust mite allergy.International journal of occupational medicine and environmental health · 2026
    Observational
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kody A WaldsteinDepartment of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, Iowa, USA.ORCID 0000-0003-0819-1158
Arman IssimovDepartment of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, Iowa, USA.
Maria GanamaDepartment of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, Iowa, USA.
Valerie JingeDepartment of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, Iowa, USA.
Stephen TilleyDepartment of Medicine, Division of Pulmonary Diseases and Critical Care Medicine and the Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Xiaoyang HuaDepartment of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, Iowa, USA.ORCID 0000-0001-6414-7712

Funding

The University of Iowa Clinical and Translational Science AwardKL2TR002536 · NCATS · UNIVERSITY OF IOWA · PI BASSUK, ALEXANDER G · 2018 to 2022
$3.3M
The nose-lung cross talk in upper respiratory virus infection induced asthma exacerbationsR01HL167271 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Xiaoyang Hua · 2023 to 2026
$2.6M
Adenosine receptors as therapeutic targets for chronic rhinosinusitisR21AI096139 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TILLEY, STEPHEN LLOYD · 2012 to 2013
$407k
NCATS NIH HHS KL2 TR002536NHLBI NIH HHS R01 HL167271NIAID NIH HHS R21 AI096139
6 · The paper itself

Abstract

backgroundUpper respiratory viral infections (URVIs) are responsible for 80% of asthma exacerbation episodes. However, the underlying mechanisms remain poorly understood.

methodsIn this study, we used a mouse model of URVI and examined the impact of URVI on asthma phenotypes and the underlying mechanisms.

resultsPreviously, we have reported that nasal-restricted infection with respiratory syncytial virus (RSV) only produces mild sino-nasal inflammation and mucus production, without causing direct lung infection. However, such nasal-restricted infection dramatically enhanced T

conclusionsTaken together, our data have shown that URVI enhances the allergic inflammatory response and AHR through a B cell‒monocyte regulatory axis.

Indexed as

AsthmaB-LymphocytesDisease Models, AnimalMonocytesAnimalsAntigens, LyChemokine CCL7FemaleLungMiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutPyroglyphidaeReceptors, CCR2Respiratory Syncytial Virus InfectionsAntigens, LyCcl7 protein, mouseCcr2 protein, mouseChemokine CCL7Ly-6C antigen, mouseReceptors, CCR2allergenallergyasthmainflammationviral rhinosinusitis

Identifiers

PMID39110115
PMCPMC11611691

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.