Evidence map›Paper›PMID 39110059›Full record

ReviewNanomedicine (London, England)2024

Advanced biopolymeric materials and nanosystems for RNA/DNA vaccines: a review.

Luis F T Pereira, João G R Tredus, Larissa O Corá, Luisa L Novacki, Gabriel E D Oliveira, Mariana Vodiani, Isabela P Dias, Rafael X V Filho, Guilherme F Picheth

Abstract readReview
In one paragraph

Review in Nanomedicine (London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Luis F T PereiraSchool of Medicine, Pontifical Catholic University of Paraná, Curitiba, PR, Brazil.
João G R TredusSchool of Medicine, Pontifical Catholic University of Paraná, Curitiba, PR, Brazil.
Larissa O CoráSchool of Medicine, Pontifical Catholic University of Paraná, Curitiba, PR, Brazil.
Luisa L NovackiSchool of Medicine,  Federal University of Paraná, Curitiba, PR, Brazil.
Gabriel E D OliveiraDepartment of Biochemistry, Federal University of Paraná, Curitiba, PR, Brazil.
Mariana VodianiDepartment of Biochemistry, Federal University of Paraná, Curitiba, PR, Brazil.
Isabela P DiasDepartment of Biochemistry, Federal University of Paraná, Curitiba, PR, Brazil.
Rafael X V FilhoDepartment of Biochemistry, Federal University of Paraná, Curitiba, PR, Brazil.
Guilherme F PichethSchool of Medicine, Pontifical Catholic University of Paraná, Curitiba, PR, Brazil.ORCID 0000-0002-2802-0180

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The post COVID-19 pandemic era has emerged with more efficient vaccines, all based on genetic materials. However, to expand the use of nucleic components as vaccines, a new generation of nanosystems particularly constructed to increase RNA/DNA stability, half-life and facilitate administration are still required. This review highlights novel developments in mRNA and pDNA vaccines formulated into nanostructures exclusively composed by biopolymeric materials. Recent advances suggest that a new generation of vaccines may arise by adapting the structural features of biopolymers with the effectiveness of nucleic acids. The advantages offered by biopolymers, such as increased stability and targeting ability may cause a revolution in the immunization field for offering promptly adaptable and effective formulations for worldwide distribution.

Indexed as

COVID-19SARS-CoV-2Vaccines, DNAAnimalsBiopolymersCOVID-19 VaccinesHumansmRNA VaccinesNanostructuresBiopolymersCOVID-19 VaccinesmRNA VaccinesVaccines, DNAchitosanmRNApDNAPEIPLAPLGAPLLvaccines

Identifiers

PMID39110059
PMCPMC11485706

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.