Evidence map›Paper›PMID 39109995›Full record

ArticleThe Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association2025

DNA Methylation Effects on Van der Woude Syndrome Phenotypic Variability.

Amanda Seaberg, Waheed Awotoye, Fang Qian, Ligiane A Machado-Paula, Lindsey Dunlay, Azeez Butali, Jeff Murray, Lina Moreno-Uribe, Aline L Petrin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Genetic-epigenetic interactions (meQTLs) in orofacial clefts etiology.medRxiv : the preprint server for health sciences · 2025
    Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Amanda SeabergCollege of Dentistry and Dental Clinics, University of Iowa, Iowa City, IA, USA.
Waheed AwotoyeCollege of Dentistry and Dental Clinics, University of Iowa, Iowa City, IA, USA.
Fang QianCollege of Dentistry and Dental Clinics, University of Iowa, Iowa City, IA, USA.
Ligiane A Machado-PaulaCollege of Dentistry and Dental Clinics, University of Iowa, Iowa City, IA, USA.
Lindsey DunlayCollege of Dentistry and Dental Clinics, University of Iowa, Iowa City, IA, USA.
Azeez ButaliCollege of Dentistry and Dental Clinics, University of Iowa, Iowa City, IA, USA.ORCID 0000-0002-1229-5964
Jeff MurrayCarver College of Medicine, University of Iowa, Iowa City, IA, USA.
Lina Moreno-UribeCollege of Dentistry and Dental Clinics, University of Iowa, Iowa City, IA, USA.
Aline L PetrinCollege of Dentistry and Dental Clinics, University of Iowa, Iowa City, IA, USA.ORCID 0000-0003-2239-8120

Funding

University of Iowa Hawkeye Intellectual and Developmental Disabilities Research Center (Hawk-IDDRC)P50HD103556 · NICHD · UNIVERSITY OF IOWA · PI Lane Strathearn · 2021 to 2026
$8.5M
Molecular Genetic Epidemiology of Cleft Lip and PalateR37DE008559 · NIDCR · UNIVERSITY OF IOWA · PI MURRAY, JEFFREY C · 2004 to 2013
$6.8M
A Twin Approach for Genome-Wide Differential DNA Methylation in Orofacial CleftingK01DE027995 · NIDCR · UNIVERSITY OF IOWA · PI PETRIN, ALINE L · 2019 to 2023
$696k
NICHD NIH HHS P50 HD103556NIDCR NIH HHS K01 DE027995NIDCR NIH HHS R37 DE008559
6 · The paper itself

Abstract

ObjectiveVan der Woude Syndrome (VWS) presents with combinations of lip pits (LP) and cleft lip and/or cleft palate (CL/P, CPO). VWS phenotypic heterogeneity even amongst relatives, suggests that epigenetic factors may act as modifiers.

Indexed as

Abnormalities, MultipleCleft LipCleft PalateCystsDNA MethylationInterferon Regulatory FactorsLipTranscription FactorsTumor Suppressor ProteinsCpG IslandsFemaleHumansMalePhenotypePromoter Regions, GeneticInterferon Regulatory FactorsIRF6 protein, humanTP63 protein, humanTranscription FactorsTumor Suppressor Proteinscleft lip and palateDNA methylationepigeneticslip pitsphenotypic variabilityVan der Woude syndrome

Identifiers

PMID39109995
PMCPMC11802890

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.