Evidence map›Paper›PMID 39109957›Full record

ArticleAdvanced healthcare materials2024

Wirelessly Actuated Microfluidic Pump and Valve for Controlled Liquid Delivery in Dental Implants.

Yilan Xu, Honglu Lin, Boyang Xiao, Hutomo Tanoto, Joel Berinstein, Alend Khoshnaw, Simon Young, Yuxiao Zhou, Xiaoguang Dong

Abstract read
In one paragraph

Article in Advanced healthcare materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yilan XuDepartment of Mechanical Engineering, Vanderbilt University, Nashville, TN, 37212, USA.
Honglu LinDepartment of Mechanical Engineering, Vanderbilt University, Nashville, TN, 37212, USA.
Boyang XiaoDepartment of Mechanical Engineering, Vanderbilt University, Nashville, TN, 37212, USA.
Hutomo TanotoDepartment of Mechanical Engineering, Texas A&M University, College Station, TX, 77840, USA.
Joel BerinsteinDepartment of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, 37212, USA.
Alend KhoshnawDepartment of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, 37212, USA.
Simon YoungKatz Department of Oral and Maxillofacial Surgery, The University of Texas Health Science Center at Houston, School of Dentistry, Houston, TX, 77054, USA.ORCID 0000-0002-8198-7083
Yuxiao ZhouDepartment of Mechanical Engineering, Texas A&M University, College Station, TX, 77840, USA.
Xiaoguang DongDepartment of Mechanical Engineering, Vanderbilt University, Nashville, TN, 37212, USA.ORCID 0000-0002-9150-4014

Funding

Wirelessly Actuated Ciliary Stent for Minimally Invasive Treatment of Cilia DysfunctionR21EB035200 · NIBIB · VANDERBILT UNIVERSITY · PI Xiaoguang Dong · 2024 to 2026
$617k
NIBIB NIH HHS R21 EB035200Vanderbilt Institute for Surgery and EngineeringVanderbilt University School of Engineering
6 · The paper itself

Abstract

Enabling minimally invasive and precise control of liquid release in dental implants is crucial for therapeutic functions such as delivering antibiotics to prevent biofilm formation, infusing stem cells to promote osseointegration, and administering other biomedicines. However, achieving controllable liquid cargo release in dental implants remains challenging due to the lack of wireless and miniaturized fluidic control mechanisms. Here wireless miniature pumps and valves that allow remote activation of liquid cargo delivery in dental implants, actuated and controlled by external magnetic fields (<65 mT), are reported. A magnet-screw mechanism in a fluidic channel to function as a piston pump, alongside a flexible magnetic valve designed to open and close the fluidic channel, is proposed. The mechanisms are showcased by storing and releasing of liquid up to 52 µL in a dental implant. The liquid cargos are delivered directly to the implant-bone interface, a region traditionally difficult to access. On-demand liquid delivery is further showed by a metal implant inside both dental phantoms and porcine jawbones. The mechanisms are promising for controllable liquid release after implant placement with minimal invasion, paving the way for implantable devices that enable long-term and targeted delivery of therapeutic agents in various bioengineering applications.

Indexed as

Dental ImplantsAnimalsDrug Delivery SystemsMicrofluidicsSwineWireless TechnologyDental Implantsimplantmagnetic actuationpumptargeted drug deliveryvalve

Identifiers

PMID39109957
PMCPMC11650432

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.