Evidence map›Paper›PMID 39109800›Full record

ArticleJournal of agricultural and food chemistry2024

Development and Application of a Liquid Chromatography-Tandem Mass Spectrometry Method for the Analysis of 20 Perfluoroalkyl Substances in Fruit and Vegetables at Sub-Parts-per-Trillion Levels.

Ruben Kause, Stefan van Leeuwen, Kerstin Krätschmer, Bob van Dooren, Rens Keppels, Helgah Makarem, L Ron A P Hoogenboom, Leontien de Pagter-de Witte, Bjorn J A Berendsen

Abstract readEvaluation Study
In one paragraph

Article in Journal of agricultural and food chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ruben KauseWageningen Food Safety Research (WFSR), Wageningen University & Research, 6708 WB Wageningen, Netherlands.ORCID 0009-0002-2609-4482
Stefan van LeeuwenWageningen Food Safety Research (WFSR), Wageningen University & Research, 6708 WB Wageningen, Netherlands.ORCID 0000-0003-4847-0768
Kerstin KrätschmerWageningen Food Safety Research (WFSR), Wageningen University & Research, 6708 WB Wageningen, Netherlands.ORCID 0000-0003-4777-8488
Bob van DoorenWageningen Food Safety Research (WFSR), Wageningen University & Research, 6708 WB Wageningen, Netherlands.
Rens KeppelsWageningen Food Safety Research (WFSR), Wageningen University & Research, 6708 WB Wageningen, Netherlands.
Helgah MakaremWageningen Food Safety Research (WFSR), Wageningen University & Research, 6708 WB Wageningen, Netherlands.
L Ron A P HoogenboomWageningen Food Safety Research (WFSR), Wageningen University & Research, 6708 WB Wageningen, Netherlands.ORCID 0000-0002-8913-5328
Leontien de Pagter-de WitteWageningen Food Safety Research (WFSR), Wageningen University & Research, 6708 WB Wageningen, Netherlands.
Bjorn J A BerendsenWageningen Food Safety Research (WFSR), Wageningen University & Research, 6708 WB Wageningen, Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In response to the European Food Safety Authority's establishment of a tolerable weekly intake (TWI) for the sum of PFOA, PFNA, PFHxS, and PFOS, a method was developed to quantify and confirm 20 PFASs at the sub-parts-per-trillion level in fruit and vegetables. Improved sensitivity was achieved by (i) increasing the sample intake, (ii) decreasing the solvent volume in the final extract, and (iii) using a highly sensitive mass spectrometer. Except for PFTrDA, target PFASs could be quantitatively determined with an apparent recovery of 90-119%, limits of quantitation down to 0.5 ng/kg, and a relative standard deviation under within-laboratory reproducibility conditions of <28%. The method was successfully applied to 215 fruit and vegetable samples obtained from local grocery stores and markets. Leafy vegetables prove to be the main vegetable category responsible to PFAS exposure, mainly of PFOA, followed by PFHpA and PFHxA.

Indexed as

FluorocarbonsFood ContaminationFruitTandem Mass SpectrometryVegetablesChromatography, High Pressure LiquidChromatography, LiquidFluorocarbonsexposurefoodLC−MS/MSPFASsvalidation

Identifiers

PMID39109800
PMCPMC11342373

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.