Evidence map›Paper›PMID 39109763›Full record

ArticleBrazilian oral research2024

Physicochemical properties and antibiofilm activity of mineral trioxide aggregate associated with farnesol.

Gabriela Mariana Castro-Núñez, Mário Tanomaru-Filho, Gisselle Moraima Chávez-Andrade, Fernanda Ferrari Esteves Torres, Roberta Bosso-Martelo, Juliane Maria Guerreiro-Tanomaru

Abstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Brazilian oral research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trends and Future Perspectives in Additive Modifications of Calcium Silicate-Based Cements: A Scoping Review (2015-2024).Australian endodontic journal : the journal of the Australian Society of Endodontology Inc · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gabriela Mariana Castro-NúñezUniversidad Catolica de Santa Maria - UCSM, School of Dentistry, Arequipa, Peru.ORCID http://orcid.org/0000-0002-2586-541X
Mário Tanomaru-FilhoUniversidade Estadual Paulista - UNESP, School of Dentistry, Department of Restorative Dentistry, Araraquara, SP, Brazil.ORCID http://orcid.org/0000-0002-2574-4706
Gisselle Moraima Chávez-AndradeUniversidade Estadual Paulista - UNESP, School of Dentistry, Department of Restorative Dentistry, Araraquara, SP, Brazil.ORCID http://orcid.org/0000-0003-1394-2139
Fernanda Ferrari Esteves TorresUniversidade Estadual Paulista - UNESP, School of Dentistry, Department of Restorative Dentistry, Araraquara, SP, Brazil.ORCID http://orcid.org/0000-0002-0631-3249
Roberta Bosso-MarteloUniversidade Federal da Bahia - UFBA, School of Dentistry, Department of Dentistry, Salvador, BA, Brazil.ORCID http://orcid.org/0000-0002-0561-2685
Juliane Maria Guerreiro-TanomaruUniversidade Estadual Paulista - UNESP, School of Dentistry, Department of Restorative Dentistry, Araraquara, SP, Brazil.ORCID http://orcid.org/0000-0003-0446-2037

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study assessed the physicochemical and antibiofilm properties of white mineral trioxide aggregate (MTA) associated with 1 or 2% of farnesol. Setting time was evaluated based on ISO 6876/2012. Radiopacity was evaluated by radiographic analysis. pH was assessed after time intervals of 1, 3, 7, 14, 21, and 28 days. Solubility (% mass loss) and volumetric change (by micro-CT) of the cements were evaluated after immersion in distilled water. The presence of voids inside the materials was assessed by using micro-CT. Antibiofilm activity against Enterococcus faecalis was evaluated by crystal violet assay and the modified direct contact test performed with biofilm previously formed on bovine root dentin for 14 days. Data were submitted to ANOVA/Tukey tests with 5% significance level. The incorporation of farnesol into MTA increased its setting time, but decreased its solubility at 30 days and its volumetric loss in all periods (p < 0.05). Radiopacity and solubility after 7 days were similar among the materials (p > 0.05). The association of farnesol showed the highest pH value after 1 and 3 days (p < 0.05). The association of farnesol with MTA promoted a decrease in the presence of voids, and increased the antimicrobial activity on biofilm biomass of E. faecalis (p < 0.05). In conclusion, the addition of farnesol can be suggested to improve the antimicrobial properties and the consistency of MTA.

Indexed as

Aluminum CompoundsBiofilmsCalcium CompoundsDrug CombinationsEnterococcus faecalisFarnesolMaterials TestingOxidesRoot Canal Filling MaterialsSilicatesSolubilityAnalysis of VarianceAnimalsCattleDentinHydrogen-Ion ConcentrationAluminum CompoundsCalcium CompoundsDrug CombinationsFarnesolmineral trioxide aggregateOxidesRoot Canal Filling MaterialsSilicates

Identifiers

PMID39109763
PMCPMC11376616

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.