Evidence map›Paper›PMID 39109516›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2024

Epigenetic mechanisms differentially regulate blood pressure and renal dysfunction in male and female Npr1 haplotype mice.

Prerna Kumar, Kandasamy Neelamegam, Chandramohan Ramasamy, Ramachandran Samivel, Huijing Xia, Daniel R Kapusta, Kailash N Pandey

Abstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Renal Tubule Cell-SpecificHypertension (Dallas, Tex. : 1979) · 2026
    Article
  3. Article
  4. Epigenetic mechanisms differentially regulate blood pressure and renal dysfunction in male and female Npr1 haplotype mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Prerna KumarDepartment of Physiology, School of Medicine, Tulane University Health Sciences Center, New Orleans, Louisiana, USA.ORCID 0000-0002-5989-1878
Kandasamy NeelamegamDepartment of Physiology, School of Medicine, Tulane University Health Sciences Center, New Orleans, Louisiana, USA.ORCID 0009-0005-2211-7693
Chandramohan RamasamyDepartment of Physiology, School of Medicine, Tulane University Health Sciences Center, New Orleans, Louisiana, USA.ORCID 0009-0002-8739-1800
Ramachandran SamivelDepartment of Physiology, School of Medicine, Tulane University Health Sciences Center, New Orleans, Louisiana, USA.ORCID 0000-0001-8301-8625
Huijing XiaDepartment of Pharmacology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.ORCID 0000-0001-7024-5693
Daniel R KapustaDepartment of Pharmacology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.ORCID 0000-0002-7593-6984
Kailash N PandeyDepartment of Physiology, School of Medicine, Tulane University Health Sciences Center, New Orleans, Louisiana, USA.ORCID 0000-0002-5430-1672

Funding

Study of ANP Receptor:Gene Targeting and ExpressionR01HL062147 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI PANDEY, KAILASH N · 1998 to 2020
$5.0M
ANP Receptor: Genetic and Epigenetic Mechanisms Regulating Blood Pressure and Kidney Injury and DysfunctionR01DK133833 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI PANDEY, KAILASH N · 2022 to 2025
$1.8M
NHLBI NIH HHS R01 HL062147NIDDK NIH HHS R01 DK133833NIH HHS DK133833NIH HHS HL062147
6 · The paper itself

Abstract

We determined the epigenetic mechanisms regulating mean arterial pressure (MAP) and renal dysfunction in guanylyl cyclase/natriuretic peptide receptor-A (GC-A/NPRA) gene-targeted mice. The Npr1 (encoding NPRA) gene-targeted mice were treated with class 1 specific histone deacetylase inhibitor (HDACi) mocetinostat (MGCD) to determine the epigenetic changes in a sex-specific manner. Adult male and female Npr1 haplotype (1-copy; Npr1

Indexed as

Blood PressureEpigenesis, GeneticReceptors, Atrial Natriuretic FactorAnimalsFemaleHistone Deacetylase InhibitorsKidneyKidney DiseasesMaleMiceatrial natriuretic factor receptor AHistone Deacetylase InhibitorsReceptors, Atrial Natriuretic FactorepigeneticshypertensionmiR‐133amocetinostatnatriuretic peptide receptor‐ANF‐κBrenal dysfunction

Identifiers

PMID39109516
PMCPMC11309581

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.