Evidence map›Paper›PMID 39109415›Full record

Trial reportAllergy2025

Impact of a drug allergy education course for non-specialists: Findings from ADAPT-A randomized crossover trial.

Michaela Lucas, Hugo W F Mak, Jasmine T Y Lee, Rishabh Kulkarni, Sophia S C Chan, Philip H Li

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Allergy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06399601 (A Training Program of Drug Allergy for Healthcare Professionals), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06399601 naunknown statusnot on this map

A Training Program of Drug Allergy for Healthcare Professionals: A Randomized Controlled Trial

TypeinterventionalSponsorThe University of Hong KongRan2024 to 2024Enrolled100ConditionsDrug AllergyArmsDrug allergy training program
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Article
  3. Bridging Global Disparities in Drug Allergy Through AI-Assisted Training for Non-Specialists: Findings From the Multinational ADAPT-2 Course.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Michaela LucasImmunology Department, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.
Hugo W F MakDivision of Rheumatology and Clinical Immunology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong.
Jasmine T Y LeeDivision of Rheumatology and Clinical Immunology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong.
Rishabh KulkarniImmunology Department, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.
Sophia S C ChanSchool of Nursing, The University of Hong Kong, Pokfulam, Hong Kong.
Philip H LiDivision of Rheumatology and Clinical Immunology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong.ORCID https://orcid.org/0000-0002-9155-9162

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe consequences of drug allergy remain a global health concern. Drug allergy is often a neglected topic and many non-specialists lack sufficient knowledge or confidence in evaluating or managing this common condition. Evidence-based interventions to better equip non-specialists to tackle drug allergy are needed. The aim of the study is to evaluate the effectiveness of an intensive educational course on drug allergy knowledge and practice of non-specialists.

methodsA randomized crossover trial (NCT06399601) was conducted among practicing physicians and nurses participating in an intensive drug allergy course-Advances in Drug Allergy & Penicillin Testing (ADAPT). Participants' baseline knowledge and self-reported practices were assessed with standardized questionnaires (scored from 0 to 100, with "satisfactory" defined as ≥60/100). Participants were randomized into two cohorts and attended ADAPT at different time points. Serial responses before and after the course were compared within and between cohorts.

resultsSeventy participants (25 physicians, 45 nurses) randomized into two groups completed the course. Baseline drug allergy knowledge (58.0 ± 19.9) and self-reported practice (36.9 ± 24.3) were unsatisfactory among non-specialists, with significantly lower scores from nurses than physicians in both domains (knowledge: 49.0 ± 17.4 vs. 74.0 ± 12.7; practice: 32.1 ± 21.3 vs. 53.3 ± 23.1; all p < 0.001). Following completion of ADAPT, participants demonstrated significant improvements in knowledge (58.0 ± 19.9 vs. 77.7 ± 15.9, p < 0.001) and self-reported practice (36.9 ± 24.3 vs. 71.0 ± 20.2, p < 0.001). All participants (100%) and 99% of participants agreed that the course improved their clinical knowledge and practice, respectively.

conclusionsADAPT, an intensive drug allergy educational course was effective in improving drug allergy knowledge and practice for non-specialists. Further longitudinal studies are required to evaluate long-term impact.

Indexed as

Drug HypersensitivityAdultCross-Over StudiesFemaleHealth Knowledge, Attitudes, PracticeHumansMaleMiddle AgedPhysiciansSurveys and Questionnairesclinical trialdrug allergyeducationmultidisciplinarynon‐allergist

Identifiers

PMID39109415
PMCPMC11804302

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.