ArticleFrontiers in psychiatry2024
The predictive validity of a Brain Care Score for late-life depression and a composite outcome of dementia, stroke, and late-life depression: data from the UK Biobank cohort.
Article in Frontiers in psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Brain care score and retinal health: structural and metabolic insights from the UK Biobank.GeroScience · 2026Article
- Association of baseline brain care score with the incidence of age-related eye diseases.Eye (London, England) · 2026Article
- Brain Health and Traumatic Brain Injury (TBI): Relationship Between Brain Care Score and Disability in Subacute-Long Term TBI.American journal of lifestyle medicine · 2026Article
- Associations of Midlife Vascular Risk Factors With Late-Life Depressive Symptoms: Findings From the ARIC Study.Journal of the American Heart Association · 2026Article
- The McCance Brain Care Score and Mortality: Evidence From a Large-Scale Population-Based Cohort.Annals of clinical and translational neurology · 2026Article
- Association Between Brain Care Score and Cognitive Performance: Findings From a Community-Based Cohort in Singapore.Brain and behavior · 2026Article
- Implementing brain health strategies in primary care: methods and baseline findings from the BHAM registry.Archives of public health = Archives belges de sante publique · 2025Article
- Younger adult women who had a stroke or at high stroke risk: Exploration of their experiences and needs.Qualitative research in medicine & healthcare · 2025Article
- Depression in older adults with epilepsy: Pathophysiology and management considerations.Epilepsy & behavior : E&B · 2025Review
- Assocation Between a Brain Care Score Derived from Participant Responses and Incident Stroke from the COSMOS Study.American journal of lifestyle medicine · 2025Article
- Brain health: a new concept to the neurologist - an initiative of the Lifestyle Medicine Commission of the Brazilian Academy of Neurology.Arquivos de neuro-psiquiatria · 2025Review
- Association of Leucocyte Telomere Length With Stroke, Dementia, and Late-Life Depression: The Role of Modifiable Risk Factors.Neurology · 2025Article
- Use of the Brain Care Score to Estimate the Risk of Incident Cerebrovascular Events in Middle-Aged Women.Neurology · 2025Article
- Knowledge and practice of healthy behaviors for dementia and stroke prevention in a United States cohort.Scientific reports · 2025Article
- Home Environment as a Therapeutic Target for Prevention and Treatment of Chronic Diseases: Delivering Restorative Living Spaces, Patient Education and Self-Care by Bridging Biophilic Design, E-Commerce and Digital Health Technologies.International journal of environmental research and public health · 2025Article
- Health-Related Behaviors and Risk of Common Age-Related Brain Diseases Across Severities of Genetic Risk.Neurology · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
27 authors.
Funding
Abstract
Introduction: The 21-point Brain Care Score (BCS) is a novel tool designed to motivate individuals and care providers to take action to reduce the risk of stroke and dementia by encouraging lifestyle changes. Given that late-life depression is increasingly recognized to share risk factors with stroke and dementia, and is an important clinical endpoint for brain health, we tested the hypothesis that a higher BCS is associated with a reduced incidence of future depression. Additionally, we examined its association with a brain health composite outcome comprising stroke, dementia, and late-life depression. Methods: The BCS was derived from the United Kingdom Biobank baseline evaluation in participants with complete data on BCS items. Associations of BCS with the risk of subsequent incident late-life depression and the composite brain health outcome were estimated using multivariable Cox proportional hazard models. These models were adjusted for age at baseline and sex assigned at birth. Results: A total of 363,323 participants were included in this analysis, with a median BCS at baseline of 12 (IQR: 11-14). There were 6,628 incident cases of late-life depression during a median follow-up period of 13 years. Each five-point increase in baseline BCS was associated with a 33% lower risk of incident late-life depression (95% CI: 29%-36%) and a 27% lower risk of the incident composite outcome (95% CI: 24%-30%). Discussion: These data further demonstrate the shared risk factors across depression, dementia, and stroke. The findings suggest that a higher BCS, indicative of healthier lifestyle choices, is significantly associated with a lower incidence of late-life depression and a composite brain health outcome. Additional validation of the BCS is warranted to assess the weighting of its components, its motivational aspects, and its acceptability and adaptability in routine clinical care worldwide.
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