Evidence map›Paper›PMID 39109298›Full record

ArticleBeilstein journal of organic chemistry2024

Discovery of antimicrobial peptides clostrisin and cellulosin from Clostridium: insights into their structures, co-localized biosynthetic gene clusters, and antibiotic activity.

Moisés Alejandro Alejo Hernandez, Katia Pamela Villavicencio Sánchez, Rosendo Sánchez Morales, Karla Georgina Hernández-Magro Gil, David Silverio Moreno-Gutiérrez, Eddie Guillermo Sanchez-Rueda, Yanet Teresa-Cruz, Brian Choi, Armando Hernández Garcia, Alba Romero-Rodríguez and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Beilstein journal of organic chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Moisés Alejandro Alejo HernandezLaboratory of Microbiology, Institute of Chemistry, National Autonomous University of Mexico , Mexico City, 04510, Mexico.ORCID https://orcid.org/0009-0005-4911-6404
Katia Pamela Villavicencio SánchezLaboratory of Microbiology, Institute of Chemistry, National Autonomous University of Mexico , Mexico City, 04510, Mexico.ORCID https://orcid.org/0009-0004-8006-2339
Rosendo Sánchez MoralesLaboratory of Microbiology, Institute of Chemistry, National Autonomous University of Mexico , Mexico City, 04510, Mexico.ORCID https://orcid.org/0009-0002-0687-6591
Karla Georgina Hernández-Magro GilLaboratory of Microbiology, Institute of Chemistry, National Autonomous University of Mexico , Mexico City, 04510, Mexico.ORCID https://orcid.org/0009-0001-6375-8017
David Silverio Moreno-GutiérrezLaboratory of Microbiology, Institute of Chemistry, National Autonomous University of Mexico , Mexico City, 04510, Mexico.ORCID https://orcid.org/0000-0002-7363-8561
Eddie Guillermo Sanchez-RuedaBiomolecular Engineering and Bionanotechnology Laboratory, Institute of Chemistry, National Autonomous University of Mexico , Mexico City, 04510, Mexico.ORCID https://orcid.org/0000-0001-7079-9282
Yanet Teresa-CruzLaboratory A-107, Biomedical Research Institute, National Autonomous University of Mexico , Mexico City, 04510, Mexico.ORCID https://orcid.org/0009-0001-4563-4846
Brian ChoiDepartment of Chemical and Biological Engineering, Chemistry and Molecular Biology, Princeton University, Princeton, NJ, USA.ORCID https://orcid.org/0000-0003-2976-8577
Armando Hernández GarciaBiomolecular Engineering and Bionanotechnology Laboratory, Institute of Chemistry, National Autonomous University of Mexico , Mexico City, 04510, Mexico.ORCID https://orcid.org/0000-0002-2401-8139
Alba Romero-RodríguezLaboratory A-107, Biomedical Research Institute, National Autonomous University of Mexico , Mexico City, 04510, Mexico.
Oscar JuárezDepartment of Biological Sciences, Illinois Institute of Technology, Chicago, Illinois 60616.
Siseth Martínez-CaballeroInstitute of Chemistry, National Autonomous University of Mexico, Mexico City, 04510, Mexico.ORCID https://orcid.org/0000-0003-4842-8447
Mario FigueroaFacultad de Química, Universidad Nacional Autónoma de México (UNAM), Ciudad de México, 04510, México.ORCID https://orcid.org/0000-0001-7004-0591
Corina-Diana CeapăLaboratory of Microbiology, Institute of Chemistry, National Autonomous University of Mexico , Mexico City, 04510, Mexico.ORCID https://orcid.org/0000-0001-8661-4211

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial resistance presents a substantial threat to global public health, demanding urgent attention and action. This study focuses on lanthipeptides, ribosomally encoded peptides that display significant structural diversity and hold promising potential as antibiotics. Genome mining was employed to locate biosynthetic gene clusters (BGCs) containing class II lanthipeptide synthetases encoded by

Indexed as

antimicrobialsgenome mininglanthipeptideslantibioticsmulti-drug resistant bacterianatural products

Identifiers

PMID39109298
PMCPMC11301040

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.