Evidence map›Paper›PMID 39109261›Full record

ArticleTransgender health2024

Higher Rates of Certain Autoimmune Diseases in Transgender and Gender Diverse Youth.

Santhi N Logel, Johsias Maru, Jax Whitehead, Cassandra Brady, Abby Walch, Michael Lasarev, Jennifer L Rehm, Kate Millington

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transgender health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Santhi N LogelDivision of Pediatric Endocrinology and Diabetes, Department of Pediatrics, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.ORCID https://orcid.org/0000-0003-2028-8518
Johsias MaruDivision of Pediatric Endocrinology, Department of Pediatrics, Benioff Children's Hospitals, University of California San Francisco, San Francisco, California, USA.
Jax WhiteheadDivision of Endocrinology, Department of Pediatrics, Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Cassandra BradyDivision of Pediatric Endocrinology and Diabetes, Department of Pediatrics, Monroe Carell Jr. Children's Hospital at Vanderbilt University, Nashville, Tennessee, USA.
Abby WalchDivision of Pediatric Endocrinology, Department of Pediatrics, Benioff Children's Hospitals, University of California San Francisco, San Francisco, California, USA.
Michael LasarevDepartment of Biostatistics and Medical Informatics, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.ORCID https://orcid.org/0000-0002-1896-2705
Jennifer L RehmDivision of Pediatric Endocrinology and Diabetes, Department of Pediatrics, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.
Kate MillingtonDivision of Endocrinology, Boston Children's Hospital, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0001-5222-5787

Funding

DIABETES, ENDOCRINOLOGY &METABOLISM TRAINING PROGRAMT32DK007418 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EDWARD C HSIAO · 1986 to 2026
$14.3M
Childhood Diabetes Clinical & Molecular Research Training ProgramT32DK077586 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI Brigid Ellen Gregg, Scott B. Reeder · 2008 to 2026
$2.4M
NIDDK NIH HHS T32 DK007418NIDDK NIH HHS T32 DK077586
6 · The paper itself

Abstract

Purpose: The objective of this study is to determine the prevalence of certain autoimmune diseases in transgender and gender diverse (TGD) youth. Methods: A multicenter, retrospective analysis was conducted from January 2013 to January 2019 of youth ≤26 years of age with concurrent diagnoses of gender dysphoria (GD) and at least one of the studied autoimmune diseases. Prevalence rates were calculated and compared to previously reported rates. Statistical significance was determined using second generation Results: During the study period, 128 of 3812 (3.4%) youth evaluated for GD had a concurrent diagnosis of at least one of the studied autoimmune diseases. Three autoimmune diseases had prevalence rates significantly higher than those previously documented in the literature (second generation Conclusion: There is an increased prevalence of certain autoimmune diseases in youth who identify as TGD presenting for subspecialty care. Limitations such as retrospective study design, selection bias, and reliance on electronic medical records make it difficult to draw wide-reaching conclusions about these findings. This study highlights the need for more research to delineate the impacts of unrecognized or untreated GD on autoimmune disease development and control.

Indexed as

autoimmune diseaseautoimmunitygender dysphoriapediatricsprevalencetransgender

Identifiers

PMID39109261
PMCPMC11299103

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.