Evidence map›Paper›PMID 39109177›Full record

ArticlebioRxiv : the preprint server for biology2024

H105A peptide eye drops promote photoreceptor survival in murine and human models of retinal degeneration.

Alexandra Bernardo-Colón, Andrea Bighinati, Shama Parween, Subrata Debnath, Ilaria Piano, Elisa Adani, Francesca Corsi, Claudia Gargini, Natalia Vergara, Valeria Marigo and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Alexandra Bernardo-ColónSection of Protein Structure and Function, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health; Bethesda, MD, USA.ORCID 0009-0009-0772-8225
Andrea BighinatiDepartment of Life Sciences, University of Modena and Reggio Emilia; 41125 Modena, Italy.ORCID 0000-0002-7584-1934
Shama ParweenCellSight Ocular Stem Cell and Regeneration Program, Sue Anschutz-Rodgers Eye Center, University of Colorado Anschutz Medical Campus; Aurora, Colorado, USA.ORCID 0000-0001-8440-2055
Subrata DebnathSection of Protein Structure and Function, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health; Bethesda, MD, USA.ORCID 0000-0003-3858-8367
Ilaria PianoDepartment of Pharmacy, University of Pisa; 56126 Pisa, Italy.ORCID 0000-0002-5073-7583
Elisa AdaniDepartment of Life Sciences, University of Modena and Reggio Emilia; 41125 Modena, Italy.ORCID 0000-0001-5294-0270
Francesca CorsiDepartment of Pharmacy, University of Pisa; 56126 Pisa, Italy.ORCID 0000-0002-9350-7948
Claudia GarginiDepartment of Pharmacy, University of Pisa; 56126 Pisa, Italy.ORCID 0000-0002-4992-9086
Natalia VergaraCellSight Ocular Stem Cell and Regeneration Program, Sue Anschutz-Rodgers Eye Center, University of Colorado Anschutz Medical Campus; Aurora, Colorado, USA.ORCID 0000-0003-4545-8181
Valeria MarigoDepartment of Life Sciences, University of Modena and Reggio Emilia; 41125 Modena, Italy.ORCID 0000-0002-4428-2084
S Patricia BecerraSection of Protein Structure and Function, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health; Bethesda, MD, USA.ORCID 0000-0001-8004-4983

Funding

Therapeutics for the chorioretinaZIAEY000438 · NEI · NATIONAL EYE INSTITUTE · PI BECERRA, S. PATRICIA · 2009 to 2025
$6.7M
ROLE OF PROTEIN INTERACTIONS IN RETINA DEVELOPMENT AND FUNCTIONZ01EY000306 · NEI · NATIONAL EYE INSTITUTE · PI BECERRA, SOFIA P · 1995 to 2008
$2.3M
Intramural NIH HHS Z01 EY000306
6 · The paper itself

Abstract

Photoreceptor death causes blinding inheritable retinal diseases, such as retinitis pigmentosa (RP). As disease progression often outpaces therapeutic advances, finding effective treatments is urgent. This study focuses on developing a targeted approach by evaluating the efficacy of small peptides derived from pigment epithelium-derived factor (PEDF), known to restrict common cell death pathways associated with retinal diseases. Peptides with affinity for the PEDF receptor, PEDF-R, (17-mer and H105A) delivered via eye drops reached the retina, efficiently promoted photoreceptor survival, and improved retinal function in RP mouse models based on both the

Identifiers

PMID39109177
PMCPMC11302621

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.