Evidence map›Paper›PMID 39109174›Full record

ArticleiScience2024

Altering heparan sulfate suppresses cell abnormalities and neuron loss in

Nicholas Schultheis, Alyssa Connell, Alexander Kapral, Robert J Becker, Richard Mueller, Shalini Shah, Mackenzie O'Donnell, Matthew Roseman, Lindsey Swanson, Sophia DeGuara and 5 more

Abstract read
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Nicholas SchultheisDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA.
Alyssa ConnellDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA.
Alexander KapralDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA.
Robert J BeckerDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA.
Richard MuellerDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA.
Shalini ShahDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA.
Mackenzie O'DonnellDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA.
Matthew RosemanDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA.
Lindsey SwansonDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA.
Sophia DeGuaraDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA.
Weihua WangCenter for Innovation in Brain Science and Department of Pharmacology, University of Arizona, Tucson, AZ 85721, USA.
Fei YinCenter for Innovation in Brain Science and Department of Pharmacology, University of Arizona, Tucson, AZ 85721, USA.
Tripti SainiDepartment of Biochemistry and Molecular Biology, Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA.
Ryan J WeissDepartment of Biochemistry and Molecular Biology, Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA.
Scott B SelleckDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA.

Funding

Research Education ComponentP30AG072980 · NIA · BANNER HEALTH · PI ALIREZA ATRI · 2021 to 2026
$24.9M
Investigating the molecular mechanisms of glycosaminoglycan assemblyR35GM150736 · NIGMS · UNIVERSITY OF GEORGIA · PI Ryan Joseph Weiss · 2023 to 2026
$1.5M
APOE Regulation of Neuron-Astrocyte Metabolic Coupling in Alzheimer's DiseaseR01AG068175 · NIA · UNIVERSITY OF ARIZONA · PI YIN, FEI · 2024 to 2025
$751k
Glysocaminoglycan Modifications as Regulators of Alzheimer's Disease-Related PathologiesR21AG070843 · NIA · PENNSYLVANIA STATE UNIVERSITY, THE · PI SELLECK, SCOTT B · 2021 to 2022
$435k
NIA NIH HHS P30 AG072980NIA NIH HHS R01 AG068175NIA NIH HHS R21 AG070843NIGMS NIH HHS R35 GM150736
6 · The paper itself

Abstract

We examined the function of heparan-sulfate-modified proteoglycans (HSPGs) in pathways affecting Alzheimer disease (AD)-related cell pathology in human cell lines and mouse astrocytes. Mechanisms of HSPG influences on

Indexed as

cell biologymolecular neuroscience

Identifiers

PMID39109174
PMCPMC11302002

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.