Evidence map›Paper›PMID 39108988›Full record

ArticleBrain & spine2024

Comparison of CT-Guided needle biopsy versus percutaneous endoscopic debridement and drainage in pathogen identification and pain outcomes for spondylodiscitis patients: A systematic review and literature review.

Nischal Acharya, Joshua S Kurtz, Kylie T Callan, Gabrielle E A Hovis, Scarlett R K Mar, Alexander Lopez, Alvin Y Chan, Hao-Hua Wu, Sohaib Z Hashmi, Nitin N Bhatia and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain & spine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nischal AcharyaDepartment of Neurological Surgery, University of California, Irvine Medical Center, Orange, CA, USA.
Joshua S KurtzDepartment of Neurological Surgery, University of California, Irvine Medical Center, Orange, CA, USA.
Kylie T CallanDepartment of Orthopaedic Surgery, University of California, Irvine Medical Center, Orange, CA, USA.
Gabrielle E A HovisDepartment of Neurological Surgery, University of California, Irvine Medical Center, Orange, CA, USA.
Scarlett R K MarDepartment of Neurological Surgery, University of California, Irvine Medical Center, Orange, CA, USA.
Alexander LopezDepartment of Neurological Surgery, University of California, Irvine Medical Center, Orange, CA, USA.
Alvin Y ChanDepartment of Neurological Surgery, University of California, Irvine Medical Center, Orange, CA, USA.
Hao-Hua WuDepartment of Orthopaedic Surgery, University of California, Irvine Medical Center, Orange, CA, USA.
Sohaib Z HashmiDepartment of Orthopaedic Surgery, University of California, Irvine Medical Center, Orange, CA, USA.
Nitin N BhatiaDepartment of Orthopaedic Surgery, University of California, Irvine Medical Center, Orange, CA, USA.
Michael Y OhDepartment of Neurological Surgery, University of California, Irvine Medical Center, Orange, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Spondylodiscitis (SD) is an infection of the intervertebral disc with involvement of the adjacent vertebral bodies. Diagnostic tests with CT-guided biopsy only provide a positive yield in 14%-48% of cases. Percutaneous endoscopic debridement and drainage (PEDD) has recently shown promise in the treatment of spondylodiscitis. Research question: The purpose of this study is to determine differences in pathogen identification and clinical outcomes for PEDD versus CT-guided needle biopsy in SD patients. Materials and methods: We conducted a systematic review of the literature using PRISMA guidelines to determine differences in positive microbiology results, perioperative complications, pain control, and long-term clinical outcomes for PEDD vs. CT-guided needle biopsy in SD patients. Results: 1078 studies were evaluated, 87 of which underwent full review. 15 studies met the inclusion and exclusion criteria, including 7 PEDD, 7 CT-guided biopsy, and 1 CT-guided biopsy vs. PEDD article, for a total of 192 PEDD patients and 604 CT-guided biopsy patients. We found 36.59% of CT-guided biopsy patients had positive microbiology results, compared to 84.38% of PEDD patients. No major perioperative complications occurred as a result of the PEDD procedure. Of the five PEDD studies that reported pain outcomes, greater than 80% of patients experienced relief after intervention. Discussion and conclusion: These results suggest that PEDD may improve pathogen identification while simultaneously reducing pain compared to CT-guided needle biopsy in SD. Although current treatment guidelines recommend CT-guided biopsy, in patients with severe back pain and suspected SD, PEDD can be considered an alternative intervention.

Indexed as

CT-Guided needle biopsyPEDDPercutaneous endoscopic debridement and drainageSpondylodiscitisVertebral osteomyelitis

Identifiers

PMID39108988
PMCPMC11301329

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.