ArticleLaryngoscope investigative otolaryngology2024
Factors associated with total laryngectomy following organ-preserving treatment of laryngeal SCC.
Article in Laryngoscope investigative otolaryngology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Concurrent chemoradiotherapy vs. total laryngectomy in locally advanced laryngeal squamous cell carcinoma: a propensity score-matched retrospective cohort study.American journal of cancer research · 2026Article
- Factors associated with total laryngectomy following organ-preserving treatment of laryngeal SCC.Laryngoscope investigative otolaryngology · 2024Article
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Authors and funding
7 authors.
Funding
Abstract
Objectives: A subset of laryngeal squamous cell carcinoma (LSCC) patients undergoing larynx preserving treatment ultimately require total laryngectomy (TL) for oncologic or functional reasons. This study aims to identify TL risk factors in these patients. Methods: Retrospective cohort study using Veterans Affairs (VA) database. T1-T4 LSCC cases treated with primary radiotherapy (XRT) or chemoradiotherapy (CRT) were assessed for TL and recurrence. Binary logistic and Cox regression and Kaplan-Meier analyses were implemented. Results: Of 5390 cases, 863 (16.0%) underwent TL. On multivariable analysis, age (adjusted odds ratio: 0.97 [0.96-0.98]; Conclusion: Advanced nodal stage was associated with reduced rates of salvage TL in the setting of local recurrence, and subsequent worse prognosis after recurrence. Conversely, advanced nodal stage may increase the risk for functional salvage TL in patients without recurrence. Level of Evidence: Level 3.
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