Evidence map›Paper›PMID 39108651›Full record

ArticleIranian journal of pharmaceutical research : IJPR

RadioLabeling of the Mutant form of Anti-PlGF Nanobody by

Tahereh Rezazadeh, Akram Sadat Tabatabaee Bafroee, Soraya Shahhosseini, Safura Jokar, Abolfazl Hasanramezani, Roghaye Arezumand

Abstract read
In one paragraph

Article in Iranian journal of pharmaceutical research : IJPR. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tahereh RezazadehDepartment of Advanced Sciences and Technologies, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran.
Akram Sadat Tabatabaee BafroeeDepartment of Biology, East Tehran Branch, Islamic Azad University, Tehran, Iran.ORCID https://orcid.org/0000-0003-0309-2206
Soraya ShahhosseiniDepartment of Pharmaceutical Chemistry and Radiopharmacy, Protein Technology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Safura JokarDepartment of Nuclear Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Abolfazl HasanramezaniDepartment of Advanced Sciences and Technologies, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran.
Roghaye ArezumandDepartment of Advanced Sciences and Technologies, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Molecular imaging is a highly effective method for diagnosing cancer and evaluating treatment. A molecular tracer often consists of two segments: A targeting segment, which can be antibodies, antibody fragments, or VHH (nanobody), and a detection segment, such as radioisotopes. The small size of VHH allows for excellent tissue penetration and fast clearance, resulting in minimal nonspecific background, which makes them appealing for use as imaging agents. Objectives: This study aims to construct Methods: The mutant form of anti-PlGF nanobody was expressed in Results: The RCP of Conclusions: The findings of this study reveal that the RCP of the labeled nanobody was above 95% after 4 hours, indicating the labeled antibody's stability. These results are promising and could be utilized in future in vitro and in vivo studies.

Indexed as

99mTc-tricarbonylPlGFRadiolabeled Nanobody

Identifiers

PMID39108651
PMCPMC11302455

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.