Evidence map›Paper›PMID 39108527›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Osteoprotegerin (OPG) and its ligands RANKL and TRAIL in falciparum, vivax and knowlesi malaria: correlations with disease severity, and B cell production of OPG.

Arya Sheela Nair, John Woodford, Jessica Loughland, Dean Andrew, Kim Piera, Fiona Amante, Timothy William, Matthew J Grigg, James S McCarthy, Nicholas M Anstey and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Arya Sheela NairQIMR Berghofer Medical Research Institute, Brisbane, Australia.
John WoodfordQIMR Berghofer Medical Research Institute, Brisbane, Australia.
Jessica LoughlandQIMR Berghofer Medical Research Institute, Brisbane, Australia.ORCID 0000-0003-2253-1577
Dean AndrewQIMR Berghofer Medical Research Institute, Brisbane, Australia.ORCID 0000-0001-6528-5439
Kim PieraMenzies School of Health Research, Darwin, Australia.
Fiona AmanteQIMR Berghofer Medical Research Institute, Brisbane, Australia.
Timothy WilliamSubang Jaya Medical Centre, Selangor, Malaysia.
Matthew J GriggMenzies School of Health Research, Darwin, Australia.ORCID 0000-0001-9914-8352
James S McCarthyQIMR Berghofer Medical Research Institute, Brisbane, Australia.
Nicholas M AnsteyMenzies School of Health Research, Darwin, Australia.ORCID 0000-0002-2192-0506
Michelle J BoyleQIMR Berghofer Medical Research Institute, Brisbane, Australia.ORCID 0000-0002-0268-232X
Bridget E BarberQIMR Berghofer Medical Research Institute, Brisbane, Australia.ORCID 0000-0003-1066-7960

Funding

Comparative incidence and clinical spectrum of Plasmodium knowlesi malaria, a longitudinal study in Sabah, MalaysiaR01AI116472 · NIAID · INFECTIOUS DISEASE SOCIETY KOTA KINABALU · PI WILLIAM, TIMOTHY · 2015 to 2019
$682k
NIAID NIH HHS R01 AI116472
6 · The paper itself

Abstract

Osteoprotegerin (OPG) is a soluble decoy receptor for receptor activator of NF-ƙB ligand (RANKL) and TNF-related apoptosis-inducing ligand (TRAIL), and is increasingly recognised as a marker of poor prognosis in a number of diseases. Here we demonstrate that in Malaysian adults with falciparum and vivax malaria, OPG is increased, and its ligands TRAIL and RANKL decreased, in proportion to disease severity. In volunteers experimentally infected with

Indexed as

falciparumknowlesiMalariaOPGosteoprotegerinRANKLreceptor activator of NF-ƙB ligandTNF-related apoptosis-inducing ligandTRAILvivax

Identifiers

PMID39108527
PMCPMC11302609

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.