Evidence map›Paper›PMID 39108515›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Chromosome X-Wide Common Variant Association Study (XWAS) in Autism Spectrum Disorder.

Marla Mendes, Desmond Zeya Chen, Worrawat Engchuan, Thiago Peixoto Leal, Bhooma Thiruvahindrapuram, Brett Trost, Jennifer L Howe, Giovanna Pellecchia, Thomas Nalpathamkalam, Roumiana Alexandrova and 10 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Marla MendesThe Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.
Desmond Zeya ChenGenetics and Genome Biology Program, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.
Worrawat EngchuanThe Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.
Thiago Peixoto LealLerner Research Institute, Genomic Medicine, Cleveland Clinic, Cleveland, OH, 44106, USA.
Bhooma ThiruvahindrapuramThe Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.
Brett TrostMolecular Medicine Program, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.
Jennifer L HoweThe Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.
Giovanna PellecchiaThe Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.
Thomas NalpathamkalamThe Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.
Roumiana AlexandrovaThe Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.
Nelson Bautista SalazarThe Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.
Ethan Alexander McKeeThe Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.
Natalia Rivera AlfaroThe Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.
Meng-Chuan LaiCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, M5G 2C1, Canada.
Sara Bandres-CigaCenter for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD, 20892, USA.
Delnaz RoshandelThe Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.
Clarrisa A BradleyThe Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.
Evdokia AnagnostouAutism Research Centre, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON, M4G 1R8, Canada.
Lei SunDepartment of Statistical Sciences, Faculty of Arts and Science, University of Toronto, Toronto, ON, M5G 1X6, Canada.
Stephen W SchererThe Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.ORCID 0000-0002-8326-1999

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autism Spectrum Disorder (ASD) displays a notable male bias in prevalence. Research into rare (<0.1) genetic variants on the X chromosome has implicated over 20 genes in ASD pathogenesis, such as

Identifiers

PMID39108515
PMCPMC11302709

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.