Evidence map›Paper›PMID 39108495›Full record

ArticleResearch square2024

Synaptic protein CSF levels relate to memory scores in individuals without dementia.

Kirsten E J Wesenhagen, Diederick M de Leeuw, Jori Tomassen, Johan Gobom, Isabelle Bos, Stephanie J B Vos, Pablo Martinez-Lage, Mikel Tainta, Julius Popp, Gwendoline Peyratout and 15 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors.

Kirsten E J WesenhagenAlzheimer Center Amsterdam, Vrije Universiteit Amsterdam, Amsterdam UMC.
Diederick M de LeeuwAlzheimer Center Amsterdam, Vrije Universiteit Amsterdam, Amsterdam UMC.
Jori TomassenAlzheimer Center Amsterdam, Vrije Universiteit Amsterdam, Amsterdam UMC.
Johan GobomSahlgrenska University Hospital.
Isabelle BosAlzheimer Center Amsterdam, Vrije Universiteit Amsterdam, Amsterdam UMC.
Stephanie J B VosAlzheimer Center Limburg, Maastricht University.
Pablo Martinez-LageCITA-Alzheimer Foundation.
Mikel TaintaCITA-Alzheimer Foundation.
Julius PoppUniversity Hospital of Lausanne.
Gwendoline PeyratoutUniversity Hospital of Lausanne.
Magda TsolakiAHEPA University Hospital, Aristotle University of Thessaloniki.
Rik VandenbergheUniversity Hospitals Leuven.
Yvonne Freund-LeviKarolinska Institutet.
Frans VerheyAlzheimer Center Limburg, Maastricht University.
Simon LovestoneUniversity of Oxford.
Johannes StrefferUniversity of Antwerp.
Valerija DobricicUniversity of Lübeck.
Kaj BlennowUniversity of Gothenburg.
Philip ScheltensAlzheimer Center Amsterdam, Vrije Universiteit Amsterdam, Amsterdam UMC.
August B SmitVU University Amsterdam.
Lars BertramUniversity of Lübeck.
Charlotte E TeunissenAmsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit.
Henrik ZetterbergSahlgrenska University Hospital.
Betty M TijmsAlzheimer Center Amsterdam, Vrije Universiteit Amsterdam, Amsterdam UMC.
Alzheimer’s Disease Neuroimaging Initiative

Funding

The effects of iron on oxidative stress and Alzheimer's biomarkers in amyloid-positive and negative elderly normalR01AG068398 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHIANG, GLORIA CHIA-YI · 2020 to 2024
$2.8M
NIA NIH HHS R01 AG068398
6 · The paper itself

Abstract

introductionWe investigated how cerebrospinal fluid levels of synaptic proteins associate with memory function in normal cognition (CN) and mild cognitive impairment (MCI), and investigated the effect of amyloid positivity on these associations.

methodsWe included 242 CN (105(43%) abnormal amyloid), and 278 MCI individuals (183(66%) abnormal amyloid) from EMIF-AD MBD and ADNI. For 181 (EMIF-AD MBD) and 36 (ADNI) proteins with a synaptic annotation in SynGO, associations with word learning recall were analysed with linear models.

resultsSubsets of synaptic proteins showed lower levels with worse recall in preclinical AD (EMIF-AD MBD: 7, ADNI: 5 proteins, none overlapping), prodromal AD (EMIF-AD MBD only, 27 proteins) and non-AD MCI (EMIF-AD MBD: 1, ADNI: 7 proteins). The majority of these associations were specific to these groups. DISCUSSION: Synaptic disturbance-related memory impairment occurred very early in AD, indicating it may be relevant to develop therapies targeting the synapse early in the disease.

Indexed as

cerebrospinal fluid proteomicsearly Alzheimer’s diseasememory performanceSynaptic proteins

Identifiers

PMID39108495
PMCPMC11302699

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.