Evidence map›Paper›PMID 39108475›Full record

ArticleResearch square2024

Ubiquitin-Proteasome System in the Different Stages of Dominantly Inherited Alzheimer's Disease.

Eric McDade, Haiyan Liu, Quoc Bui, Jason Hassenstab, Brian Gordon, Tammie Benzinger, Yuanyuan Shen, Jigyasha Timsina, Lihua Wang, Yun Ju Sung and 28 more

Abstract readPreprint
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Psychedelics in treatment-resistant depression: a comprehensive review of mechanisms, clinical evidence, and recommendations.Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2026
    Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

38 authors.

Eric McDadeWashington University in St. Louis.ORCID 0000-0002-6764-3866
Haiyan Liu
Quoc Bui
Jason Hassenstab
Brian GordonWashington University in St. Louis.ORCID 0000-0003-2109-2955
Tammie BenzingerWashington University in St. Louis.ORCID 0000-0002-8114-0552
Yuanyuan Shen
Jigyasha Timsina
Lihua Wang
Yun Ju SungWashington University Medical School.ORCID 0000-0002-8021-4070
Celeste KarchWashington University in St. Louis.ORCID 0000-0002-6854-5547
Alan RentonNash Family Department of Neuroscience and Ronald Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA: Departments of Neurology and Genetics and Ge.ORCID 0000-0001-6702-8268
Alisha Daniels
John MorrisWashington University School of Medicine.
Chengjie Xiong
Laura IbanezWashington University in St. Louis.
Richard Perrin
Jorge J Llibre-Guerra
Gregory DayMayo Clinic in Florida.ORCID 0000-0001-5133-5538
Charlene Supnet-Bell
Xiong Xu
Sarah Berman
Jasmeer ChhatwalMassachusetts General Hospital, Brigham and Women's Hospital, Harvard Medical School.ORCID 0000-0002-7792-1698
Takeshi IkeuchiNiigata University, Brain Research Institute.ORCID 0000-0001-8828-8085
Kensaku KasugaDepartment of Molecular Genetics, Brain Research Institute, Niigata University.ORCID 0000-0002-2178-0769
Yoshiki Niimi
Edward Huey
Peter SchofieldNeuroscience Research Australia.ORCID 0000-0003-2967-9662
Natalie Ryan
Mathias JuckerUniversity of Tübingen.
Christoph LaskeEberhard-Karls University Tübingen.
Johannes LevinLudwig-Maximilians-Universität.ORCID 0000-0001-5092-4306
Jonathan Vöglein
Jee Hoon RohKorea University College of Medicine.ORCID 0000-0002-3243-0529
Francisco Lopera
Randall BatemanDepartment of Neurology, Washington University School of Medicine.ORCID 0000-0002-7729-1702
Carlos CruchagaWashington University.ORCID 0000-0002-0276-2899

Funding

Project 1U19AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI Laurel A Beckett · 2016 to 2026
$226.7M
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
DIAN-TU: Tau Next Generation Prevention Trial - Administrative SupplementR01AG068319 · NIA · WASHINGTON UNIVERSITY · PI RANDALL J BATEMAN · 2020 to 2026
$81.4M
Early Onset AD Consortium - the LEAD Study (LEADS)U01AG057195 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI APOSTOLOVA, LIANA G, CARRILLO, MARIA C · 2018 to 2023
$70.3M
Smartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI JOHN MORRIS · 1985 to 2026
$69.5M
Imaging CoreU19AG032438 · NIA · WASHINGTON UNIVERSITY · PI BATEMAN, RANDALL J · 2010 to 2025
$53.9M
The natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 2005 to 2025
$49.5M
DIAN-TU Next Generation Prevention Trial - Data Request Management SupplementR01AG053267 · NIA · WASHINGTON UNIVERSITY · PI BATEMAN, RANDALL J · 2017 to 2023
$34.9M
Research Education ComponentP30AG066444 · NIA · WASHINGTON UNIVERSITY · PI Susan Lynn Stark · 2020 to 2026
$28.7M
A Phase-2b, Double-Blind, Randomized Controlled Trial to Evaluate the Activity and Safety of Inebilizumab in Anti-N-methyl-D-aspartate receptor (NMDAR) Encephalitis and Assess Markers of DiseaseU01NS120901 · NINDS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Stacey Lynn Clardy · 2021 to 2026
$19.6M
Cross Sectional and Longitudinal Racial Disparity in Molecular Biomarkers of Alzheimer DiseaseR01AG067505 · NIA · WASHINGTON UNIVERSITY · PI XIONG, CHENGJIE · 2020 to 2024
$14.7M
USING QUANTITATIVE TRAITS TO IDENTIFY NOVEL GENES FOR ALZHEIMERS DISEASE AND OTHER COMPLEX TRAITSRF1AG053303 · NIA · WASHINGTON UNIVERSITY · PI CLIMER, SHARLEE, CRUCHAGA, CARLOS · 2016 to 2020
$4.0M
NCATS NIH HHS UL1 TR002345NIA NIH HHS K23 AG064029NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG026276NIA NIH HHS P30 AG066444NIA NIH HHS R01 AG044546NIA NIH HHS R01 AG053267NIA NIH HHS R01 AG067505NIA NIH HHS R01 AG068319NIA NIH HHS RF1 AG053303NIA NIH HHS RF1 AG053550NIA NIH HHS RF1 AG058501NIA NIH HHS RF1 AG074007NIA NIH HHS U01 AG057195NIA NIH HHS U01 AG058922NIA NIH HHS U19 AG024904NIA NIH HHS U19 AG032438NINDS NIH HHS U01 NS120901
6 · The paper itself

Abstract

This study explored the role of the ubiquitin-proteasome system (UPS) in dominantly inherited Alzheimer's disease (DIAD) by examining changes in cerebrospinal fluid (CSF) levels of UPS proteins along with disease progression, AD imaging biomarkers (PiB PET, tau PET), neurodegeneration imaging measures (MRI, FDG PET), and Clinical Dementia Rating

Identifiers

PMID39108475
PMCPMC11302696

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.