Evidence map›Paper›PMID 39108472›Full record

ArticleResearch square2024

Pro-Inflammatory Effects of Inhaled Great Salt Lake Dust Particles.

Jacob M Cowley, Cassandra E Deering-Rice, John G Lamb, Erin G Romero, Marysol Almestica-Roberts, Samantha N Serna, Lili Sun, Kerry E Kelly, Ross T Whitaker, Jenna Cheminant and 2 more

Abstract readPreprint
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Jacob M CowleyUniversity of Utah.
Cassandra E Deering-RiceUniversity of Utah.
John G LambUniversity of Utah.
Erin G RomeroUniversity of Utah.
Marysol Almestica-RobertsUniversity of Utah.
Samantha N SernaUniversity of Utah.
Lili SunUniversity of Utah.
Kerry E KellyUniversity of Utah.
Ross T WhitakerUniversity of Utah.
Jenna CheminantUniversity of Utah.
Alessandro VenosaUniversity of Utah.
Christopher A ReillyUniversity of Utah.

Funding

TRP Channels and Air PollutionR01ES017431 · NIEHS · UNIVERSITY OF UTAH · PI REILLY, CHRISTOPHER A · 2009 to 2024
$5.3M
Role of Surfactant Protein-C Mutation and Ozone Exposure in the Exacerbation of Pulmonary FibrosisR01ES032553 · NIEHS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI VENOSA, ALESSANDRO · 2021 to 2025
$2.1M
Pulmonary Epithelial TRPV3 and Wood Smoke InjuryR01ES027015 · NIEHS · UNIVERSITY OF UTAH · PI REILLY, CHRISTOPHER A · 2017 to 2021
$1.7M
NIEHS NIH HHS R01 ES017431NIEHS NIH HHS R01 ES027015NIEHS NIH HHS R01 ES032553
6 · The paper itself

Abstract

Background: Climatological shifts and human activities have decimated lakes worldwide. Water in the Great Salt Lake, Utah, USA is at near record lows which has increased risks for exposure to windblown dust from dried lakebed sediments. Formal studies evaluating the health effects of inhaled Great Salt Lake dust (GSLD) have not been performed despite the belief that the dust is harmful. The objectives of this study were to illustrate windblown dust events, assess the impact of inhaled dust on the lungs, and to identify mechanisms that could contribute to the effects of GSLD in the lungs. Results: An animation, hourly particle and meteorological data, and images illustrate the impact of dust events on the Salt Lake Valley/Wasatch front airshed. Great Salt Lake sediment and PM Conclusions: This study suggests that windblown dust from Great Salt Lake and similar lake sediments could pose a risk to humans via mechanisms including the activation of TRPV1/V3, TLR4, and possibly oxidative stress.

Indexed as

Climate ChangeDustGreat Salt LakeLipopolysaccharidesParticulate PollutionPulmonary InflammationSaline LakeToll-like receptor-4Transient receptor potential (TRP) channelTransition Metal

Identifiers

PMID39108472
PMCPMC11302694

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.