Evidence map›Paper›PMID 39108311›Full record

ArticleFrontiers in neuroscience2024

Corticotropin-releasing factor and GABA in the ventral tegmental area modulate partner preference formation in male and female prairie voles (

Kyle Richard Gossman, Camryn Serra Lowe, Adrianna Kirckof, Sydney Vanmeerhaeghe, Adam Steven Smith

Abstract read
In one paragraph

Article in Frontiers in neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kyle Richard GossmanDepartment of Pharmacology and Toxicology, University of Kansas, Lawrence, KS, United States.
Camryn Serra LoweDepartment of Pharmacology and Toxicology, University of Kansas, Lawrence, KS, United States.
Adrianna KirckofDepartment of Pharmacology and Toxicology, University of Kansas, Lawrence, KS, United States.
Sydney VanmeerhaegheDepartment of Pharmacology and Toxicology, University of Kansas, Lawrence, KS, United States.
Adam Steven SmithDepartment of Pharmacology and Toxicology, University of Kansas, Lawrence, KS, United States.

Funding

KU Post-Baccalaureate Research Education Program (PREP)R25GM078441 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI V GUSTAVO BLANCO, Paulyn Cartwright · 2006 to 2026
$6.6M
Neurocircuit of Partner-seeking Following Social LossR01MH133123 · NIMH · UNIVERSITY OF KANSAS LAWRENCE · PI Adam Steven Smith · 2023 to 2026
$2.6M
Structural and functional connectivity of the social decision-making networkR01NS113104 · NINDS · UNIVERSITY OF KANSAS LAWRENCE · PI SMITH, ADAM STEVEN · 2019 to 2023
$1.9M
NIGMS NIH HHS R25 GM078441NIMH NIH HHS R01 MH133123NINDS NIH HHS R01 NS113104
6 · The paper itself

Abstract

Introduction: The mesolimbic reward system is associated with the promotion and rewarding benefits of social relationships. In the socially monogamous prairie vole ( Methods: We used pharmacological manipulation to examine how GABA and CRF signaling in the VTA modulate partner preference formation in male and female prairie voles. Specifically, we used a 3 h partner preference test, a social choice test, to assess the formation of a partner preference following an infused bicuculline and CRF during a 1 h cohabitation and muscimol and CP154526, a CRFR1 antagonist, during a 24 h cohabitation with an opposite-sex conspecific. Results: Our study demonstrated that bicuculline, a GABA Conclusion: This study demonstrated that GABA and CRF inputs into the VTA is necessary for the formation of a partner preference in male and female prairie voles.

Indexed as

CRFGABApair bondpartner preferenceprairie volesventral tegmental area

Identifiers

PMID39108311
PMCPMC11300346

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.