Evidence map›Paper›PMID 39108051›Full record

ArticleAdvanced healthcare materials2025

Sensitive Colorimetric Lateral Flow Assays Enabled by Platinum-Group Metal Nanoparticles with Peroxidase-Like Activities.

Shikuan Shao, Xiaochuan Wang, Caroline Sorial, Xiaohan Sun, Xiaohu Xia

Abstract read
In one paragraph

Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Can nanozymes achieve more than enzymes?Nature reviews. Materials · 2026
    Article
  2. Peroxidase-Mimicking Nanozymes for Rapid Detection of Infectious Diseases.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shikuan ShaoDepartment of Chemistry, University of Central Florida, Orlando, FL, 32816, USA.
Xiaochuan WangSchool of Social Work, College of Health Professions and Sciences, University of Central Florida, Orlando, FL, 32816, USA.
Caroline SorialDepartment of Health Sciences, College of Health Professions and Sciences, University of Central Florida, Orlando, FL, 32816, USA.
Xiaohan SunDepartment of Chemistry, University of Central Florida, Orlando, FL, 32816, USA.
Xiaohu XiaDepartment of Chemistry, University of Central Florida, Orlando, FL, 32816, USA.ORCID 0000-0002-6372-7712

Funding

Improving ELISA Technology using Ultra-efficient Peroxidase MimicsR01EB035519 · NIBIB · UNIVERSITY OF CENTRAL FLORIDA · PI Xiaohu Xia · 2024 to 2026
$825k
National Institute of Food and Agriculture 2020-67021-31257NIBIB NIH HHS R01 EB035519NIH HHS R01EB035519University of Central Florida
6 · The paper itself

Abstract

The last several decades have witnessed the success and popularity of colorimetric lateral flow assay (CLFA) in point-of-care testing. Driven by increasing demand, great efforts have been directed toward enhancing the detection sensitivity of CLFA. Recently, platinum-group metal nanoparticles (PGM NPs) with peroxidase-like activities have emerged as a type of promising colorimetric labels for enhancing the sensitivity of CLFA. By incorporating a simple and rapid post-treatment process, the PGM NP-based CLFAs are orders of magnitude more sensitive than conventional gold nanoparticle-based CLFAs. In this perspective, the study begins with introducing the design, synthesis, and characterization of PGM NPs with peroxidase-like activities. The current techniques for surface modification of PGM NPs are then discussed, followed by operation and optimization of PGM NP-based CLFAs. Afterward, opinions are provided on the social impact of PGM NP-based CLFAs. Lastly, this perspective is concluded with an outlook of future research directions in this emerging field, where the challenges and opportunities are discussed.

Indexed as

ColorimetryMetal NanoparticlesPeroxidasePlatinumGoldHumansGoldPeroxidasePlatinumcatalysisdetectionlateral flow assaynanoparticlesperoxidase

Identifiers

PMID39108051
PMCPMC11799360

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.