Evidence map›Paper›PMID 39107706›Full record

ArticleBMC primary care2024

Stakeholder-informed pragmatic trial protocol of the TabCAT-BHA for the detection of cognitive impairment in primary care.

Alissa Bernstein Sideman, Huong Q Nguyen, Annette Langer-Gould, Eric A Lee, Soo Borson, Ernest Shen, Elena Tsoy, Mayra Macias, Collette Goode, Katherine Rankin and 2 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC primary care, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06090578 (A Pragmatic Trial of the TabCAT Brain Health Assessment for the Detection of Cognitive Impairment in Primary Care), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06090578 narecruitingnot on this map

A Pragmatic Trial of the TabCAT Brain Health Assessment for the Detection of Cognitive Impairment in Primary Care

TypeinterventionalSponsorUniversity of California, San FranciscoRan2023 to 2026Enrolled180,000ConditionsMild Cognitive Impairment, DementiaArmsTabCAT Brain Health Assessment Clinical Pathway
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Bridging the diagnostic gap: Expanding dementia care navigation for timely diagnosis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  2. Review
  3. Enhancing early detection of cognitive impairment in primary care with the TabCAT-BHA.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alissa Bernstein Sideman *Department of Neurology, University of California, San Francisco, San Francisco, USA.
Huong Q Nguyen *Department of Research and Evaluation, Kaiser Permanente Southern California, Southern California Permanente Medical Group, 100 S. Los Robles Avenue, 2nd Floor, Pasadena, CA, 91101, USA. huong.q2.nguyen@kp.org.
Annette Langer-GouldDepartment of Research and Evaluation, Kaiser Permanente Southern California, Southern California Permanente Medical Group, 100 S. Los Robles Avenue, 2nd Floor, Pasadena, CA, 91101, USA.
Eric A LeeDepartment of Clinical Sciences, Kaiser Permanente Bernard J Tyson School of Medicine, Pasadena, USA.
Soo BorsonDepartment of Research and Evaluation, Kaiser Permanente Southern California, Southern California Permanente Medical Group, 100 S. Los Robles Avenue, 2nd Floor, Pasadena, CA, 91101, USA.
Ernest ShenDepartment of Research and Evaluation, Kaiser Permanente Southern California, Southern California Permanente Medical Group, 100 S. Los Robles Avenue, 2nd Floor, Pasadena, CA, 91101, USA.
Elena TsoyDepartment of Neurology, University of California, San Francisco, San Francisco, USA.
Mayra MaciasDepartment of Research and Evaluation, Kaiser Permanente Southern California, Southern California Permanente Medical Group, 100 S. Los Robles Avenue, 2nd Floor, Pasadena, CA, 91101, USA.
Collette GoodeDepartment of Neurology, University of California, San Francisco, San Francisco, USA.
Katherine RankinDepartment of Neurology, University of California, San Francisco, San Francisco, USA.
Joel KramerDepartment of Neurology, University of California, San Francisco, San Francisco, USA.
Katherine L PossinDepartment of Neurology, University of California, San Francisco, San Francisco, USA.

Funding

Research Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Gil Dan Rabinovici · 2019 to 2026
$36.9M
Augmenting Nurse Support and EHR Integration for the Pragmatic Trial of the UCSF-BHAU01NS128913 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Katherine Laurel Possin · 2022 to 2026
$8.2M
The UCSF Brain Health Assessment for the Detection of Cognitive Impairment Among Diverse Populations in Primary CareUH3NS105557 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI POSSIN, KATHERINE LAUREL · 2019 to 2021
$4.9M
Reimagining Precision Medicine Approaches to AD DiagnosisR35AG072362 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI POSSIN, KATHERINE LAUREL, RABINOVICI, GIL DAN · 2021 to 2025
$4.8M
Mapping the Dynamics of Caregiver Burden in Alzheimer's DiseaseK01AG059840 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SIDEMAN, ALISSA BERNSTEIN · 2020 to 2024
$652k
NIA NIH HHS K01 AG059840NIA NIH HHS P30 AG062422NIA NIH HHS R35 AG072362NINDS NIH HHS U01 NS128913NINDS NIH HHS U01NS128913NINDS NIH HHS UH3 NS105557
6 · The paper itself

Abstract

backgroundCognitive impairment and dementia are frequently under-recognized. Health system strategies anchored in primary care are essential to address gaps in timely, comprehensive diagnosis. The goal of this paper is to describe the adaptation of a tablet-based brain health assessment (TabCAT-BHA) intervention and the study protocol to test its effectiveness in improving the detection of cognitive impairment, including dementia.

methodsThis mixed-methods, pragmatic, cluster randomized, hybrid effectiveness-implementation trial is being conducted in two 18-month waves with 26 Kaiser Permanente Southern California primary care clinics, with 13 serving as intervention clinics and 13 as usual care clinics. Patients 65 years and older with memory concerns (n ~ 180,000) receiving care at the 26 clinics will be included in the analyses. Primary care clinics are provided the following practice supports as part of the TabCAT-BHA intervention: brief education and training on neurocognitive disorders and study workflows; digital tools to assess cognitive function and support clinician decision making and documentation; and registered nurse support during the work-up and post-diagnosis periods for primary care providers, patients, and families. The intervention was adapted based on engagement with multiple levels of clinical and operational leaders in the healthcare system. Effectiveness outcomes include rates of cognitive impairment diagnosis in primary care and rates of completed standardized cognitive assessments and specialist referrals with incident diagnoses. Implementation outcomes include acceptability-appropriateness-feasibility, adoption, and fidelity.

resultsWe identified seven themes organized by system-, provider-, and patient-level domains that were used to adapt the TabCAT-BHA intervention. Accordingly, changes were made to the provider education, diagnostic work-up, and post-diagnostic support. Results will be reported in fall of 2027.

conclusionsOur engagement with multiple primary and specialty care clinical and operational leaders to adapt the TabCAT-BHA intervention to these primary care clinics has informed the protocol to evaluate the intervention's effectiveness for improving the detection of cognitive impairment, including dementia, in an integrated healthcare system. TRIAL REGISTATION: Clinicaltrials.gov: NCT06090578 (registered 10/24/23).

Indexed as

Cognitive DysfunctionPrimary Health CareAgedCaliforniaComputers, HandheldDementiaFemaleHumansPragmatic Clinical Trials as TopicStakeholder ParticipationCognitive impairmentDementiaDetectionDigital cognitive assessmentsPrimary care

Identifiers

PMID39107706
PMCPMC11302096

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.