Evidence map›Paper›PMID 39107681›Full record

ArticleBMC neurology2024

COVID-19 related acute necrotizing encephalopathy and acute myocarditis in an adult female: a novel case report of brain injury and myocarditis.

Chang Xu, Yuyi Sha, Jianneng Pan, Tao Pan, Xiaoyang Zhou, Hua Wang, Zhaojun Xu, Bixin Chen

Abstract readCase Reports
In one paragraph

Article in BMC neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chang Xu *Department of Intensive Care Medicine, Ningbo No. 2 Hospital, Ningbo, Zhejiang, China.
Yuyi Sha *Department of Intensive Care Medicine, Ningbo No. 2 Hospital, Ningbo, Zhejiang, China.
Jianneng PanDepartment of Intensive Care Medicine, Ningbo No. 2 Hospital, Ningbo, Zhejiang, China.
Tao PanDepartment of Intensive Care Medicine, Ningbo No. 2 Hospital, Ningbo, Zhejiang, China.
Xiaoyang ZhouDepartment of Intensive Care Medicine, Ningbo No. 2 Hospital, Ningbo, Zhejiang, China.
Hua WangDepartment of Intensive Care Medicine, Ningbo No. 2 Hospital, Ningbo, Zhejiang, China.
Zhaojun XuDepartment of Intensive Care Medicine, Ningbo No. 2 Hospital, Ningbo, Zhejiang, China.
Bixin ChenDepartment of Intensive Care Medicine, Ningbo No. 2 Hospital, Ningbo, Zhejiang, China. icm1373@163.com.

Funding

the key discipline of Ningbo No. 2 Hospital No. 2023-Y06Zhejiang Medicine and Health Science and Technology Project No. 2021KY1027
6 · The paper itself

Abstract

backgroundAcute necrotizing encephalopathy (ANE) and myocarditis are both acute, life-threatening conditions that can be triggered by COVID-19. We report a case of sequential ANE and myocarditis following a COVID-19 infection. CASE PRESENTATION: A 27-year-old female patient was brought to the emergency department due to episodes of fever for two days and a 9-h altered state of consciousness. Her condition rapidly developed into stuporous and hemodynamic instability within serval hours. Veno-arterial extracorporeal membrane oxygenation (ECMO) was rapidly initiated with other supportive treatments. The following-up MRI showed bilateral, symmetrically distributed lesions in the brainstem, bilateral hippocampal regions, and bilateral basal ganglia, consistent with ANE. The diagnosis was confirmed through the detection of SARS-CoV-2 and the exclusion of other potential causes. After weeks of medical treatment, her condition stabilized, and she was transferred for further rehabilitation treatment.

conclusionsThis case study indicates that COVID-19 may simultaneously and rapidly affect the central nervous system and cardiovascular system, leading to poor outcomes. Accurate diagnosis and timely invasive bridging therapy, when necessary, can be lifesaving. Further exploration of potential mechanisms underlying COVID-19 central nervous system (CNS) and cardiovascular system manifestations will be important.

Indexed as

COVID-19Leukoencephalitis, Acute HemorrhagicMyocarditisAdultExtracorporeal Membrane OxygenationFemaleHumansMagnetic Resonance ImagingSARS-CoV-2Acute necrotizing encephalopathyCase reportCOVID-19ECMOMyocarditis

Identifiers

PMID39107681
PMCPMC11302840

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.