Evidence map›Paper›PMID 39107544›Full record

ArticleFunctional & integrative genomics2024

SIGMAR1 targets AMPK/ULK1 pathway to inhibit SH-SY5Y cell apoptosis by regulating endoplasmic reticulum stress and autophagy.

Min Kong, Zhiheng Chen, Zhiqiang Lin, Ping Yin, Qin Zhao

Abstract read
PubMed Publisher
In one paragraph

Article in Functional & integrative genomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. The Role of Sigmar1 in Autophagy Regulation and Disease Therapy.International journal of molecular sciences · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Min KongDepartment of Pediatric, the Third Xiangya Hospital of Central South University, Changsha, 410000, Hunan, China.
Zhiheng ChenDepartment of Pediatric, the Third Xiangya Hospital of Central South University, Changsha, 410000, Hunan, China.
Zhiqiang LinDepartment of Neurology, The Third Xiangya Hospital of Central South University, Changsha, 410000, Hunan, China.
Ping YinDepartment of Blood Transfusion, the Third Xiangya Hospital of Central South University, Changsha, 410000, Hunan, China.
Qin ZhaoDepartment of Pediatric, the Third Xiangya Hospital of Central South University, Changsha, 410000, Hunan, China. 21862847@qq.com.

Funding

Natural Science Foundation of Hunan Provincial No. 2017JJ2365
6 · The paper itself

Abstract

Distal hereditary motor neuropathy (dHMN) is a progressive neurological disease characterized by distal limb muscle weakness and amyotrophy. Sigma 1 receptor (σ1R), a gene product of SIGMAR1, mutations have been reported to induce dHMN, but its mechanism remains unknown. This study aims to explore the effect of C238T and 31_50del mutations in σ1R on neuronal SH-SY5Y cell functions. The SH-SY5Y cells that overexpressed σ1R, C238T mutant σ1R (σ1R

Indexed as

ApoptosisAutophagyAutophagy-Related Protein-1 HomologEndoplasmic Reticulum StressReceptors, sigmaSigma-1 ReceptorAMP-Activated Protein KinasesCell Line, TumorHumansIntracellular Signaling Peptides and ProteinsMutationSignal TransductionUnfolded Protein ResponseAMP-Activated Protein KinasesAutophagy-Related Protein-1 HomologIntracellular Signaling Peptides and ProteinsReceptors, sigmaSigma-1 ReceptorULK1 protein, human31_50delAMPKC238TdHMNULK1σ1R

Identifiers

PMID39107544

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.