Evidence map›Paper›PMID 39107377›Full record

ArticleCommunications biology2024

Depletion of essential mycobacterial gene glmM reduces pathogen survival and induces host-protective immune responses against tuberculosis.

Meetu Agarwal, Ashima Bhaskar, Biplab Singha, Suparba Mukhopadhyay, Isha Pahuja, Archna Singh, Shivam Chaturvedi, Nisheeth Agarwal, Ved Prakash Dwivedi, Vinay Kumar Nandicoori

Abstract read
In one paragraph

Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Meetu Agarwal *Signal Transduction Laboratory, National Institute of Immunology, New Delhi, India. meetuagarwal2388@gmail.com.ORCID 0000-0003-3682-1372
Ashima BhaskarImmunobiology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India.
Biplab SinghaSignal Transduction Laboratory, National Institute of Immunology, New Delhi, India.
Suparba MukhopadhyayImmunobiology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India.
Isha PahujaImmunobiology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India.
Archna SinghCSIR - Institute of Genomics and Integrative Biology, Mall Road, Delhi, India.
Shivam ChaturvediImmunobiology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India.
Nisheeth AgarwalTranslational Health Science and Technology Institute (THSTI), Faridabad, India.ORCID 0000-0001-9203-3026
Ved Prakash DwivediImmunobiology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India.
Vinay Kumar Nandicoori *Signal Transduction Laboratory, National Institute of Immunology, New Delhi, India. vinaykn@ccmb.res.in.ORCID 0000-0002-5682-4178

Funding

Department of Biotechnology, Ministry of Science and Technology (DBT) BT/PR13522/COE/34/27/2015Department of Science and Technology, Ministry of Science and Technology (DST) DST/INSPIRE/04/2019/002743)
6 · The paper itself

Abstract

The limitations of TB treatment are the long duration and immune-dampening effects of anti-tuberculosis therapy. The Cell wall plays a crucial role in survival and virulence; hence, enzymes involved in its biosynthesis are good therapeutic targets. Here, we identify Mycobacterium tuberculosis (Mtb) GlmM, (GlmM

Indexed as

Bacterial ProteinsMacrophagesMycobacterium tuberculosisTuberculosisAnimalsDisease Models, AnimalFemaleHost-Pathogen InteractionsHumansMiceMice, Inbred C57BLBacterial Proteins

Identifiers

PMID39107377
PMCPMC11303689

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.