Evidence map›Paper›PMID 39107317›Full record

ArticleNature communications2024

Prefrontal neuronal dynamics in the absence of task execution.

Shusen Pu, Wenhao Dang, Xue-Lian Qi, Christos Constantinidis

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. The cost of efficiency in flexible neural representations.bioRxiv : the preprint server for biology · 2026
    Article
  2. Orthogonal-Rotational Dynamics Supports Efficient Encoding and Updating for Streaming Information in Working Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Shusen Pu *Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.ORCID 0000-0003-0148-1734
Wenhao Dang *Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.
Xue-Lian QiDepartment of Neurobiology & Anatomy, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA.
Christos ConstantinidisDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA. Christos.Constantinidis.1@vanderbilt.edu.ORCID 0000-0001-7441-022X

Funding

Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Lea K Davis · 2020 to 2026
$10.3M
NEUROPHYSIOLOGICAL EFFECTS OF TRAINING IN VISUAL COGNITIVE TASKSR01EY017077 · NEI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CHRISTOS CONSTANTINIDIS · 2006 to 2026
$6.0M
NEI NIH HHS R01 EY017077NICHD NIH HHS P50 HD103537U.S. Department of Health & Human Services | NIH | National Eye Institute (NEI) R01EY017077
6 · The paper itself

Abstract

Prefrontal cortical activity represents stimuli in working memory tasks in a low-dimensional manifold that transforms over the course of a trial. Such transformations reflect specific cognitive operations, so that, for example, the rotation of stimulus representations is thought to reduce interference by distractor stimuli. Here we show that rotations occur in the low-dimensional activity space of prefrontal neurons in naïve male monkeys (Macaca mulatta), while passively viewing familiar stimuli. Moreover, some aspects of these rotations remain remarkably unchanged after training to perform working memory tasks. Significant training effects are still present in population dynamics, which further distinguish correct and error trials during task execution. Our results reveal automatic functions of prefrontal neural circuits allow transformations that may aid cognitive flexibility.

Indexed as

Macaca mulattaMemory, Short-TermNeuronsPrefrontal CortexAnimalsCognitionMalePhotic Stimulation

Identifiers

PMID39107317
PMCPMC11303542

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.