ArticleNature communications2024
Bone controls browning of white adipose tissue and protects from diet-induced obesity through Schnurri-3-regulated SLIT2 secretion.
Abstract read
In one paragraph
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- [Recent Advances in the Interorgan Regulatory Roles of Adipose Tissue].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Pooled it
- Slit2/Robo Signaling Restores Diabetic Erectile Function via Neurovascular Remodeling.Andrology · 2026Article
- Bone as an endocrine regulator of lipid and energy metabolism.Reviews in endocrine & metabolic disorders · 2026Review
- Activating the Osteoblastic USP26 Pathway Alleviates Multi-Organ Fibrosis by Decreasing Insulin Resistance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Cellular mechanisms of osteoporosis: A comprehensive perspective on ferroptosis, cuproptosis and lipid metabolism abnormalities.Biomaterials translational · 2026Review
- From nerve to bone: a tale of autonomic nervous system, bone cells, and beyond.Military Medical Research · 2026Review
- Integrative Omics Defines Metabolic Biomarkers and Genetic Regulatory Mechanisms of Mortality Risk.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The role of bone in whole-body energy metabolism.Nature reviews. Endocrinology · 2025Review
- Axon guidance cue SLIT2 regulates the murine skeletal stem cell niche through sympathetic innervation.The Journal of clinical investigation · 2025Article
- Effects of Lipid Metabolites and Cross Organ Lipid Metabolism Regulation on Bone Homeostasis.Aging and disease · 2025Review
- Viridicatol from the Deep-Sea-Derived Fungus Alleviates Bone Loss by Targeting the Wnt/SHN3 Pathway.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Bone-derived factors mediate crosstalk between skeletal and extra-skeletal organs.Bone research · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors.
Zan Li *State Key Laboratory of Cellular Stress Biology, Cancer Research Center, School of Medicine, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, People's Republic of China.ORCID 0000-0002-4873-4471
Baohong Shi *State Key Laboratory of Cellular Stress Biology, Cancer Research Center, School of Medicine, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, People's Republic of China.
Na Li *State Key Laboratory of Cellular Stress Biology, Cancer Research Center, School of Medicine, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, People's Republic of China.
Jun SunDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0001-9099-1829
Xiangchen ZengState Key Laboratory of Cellular Stress Biology, Cancer Research Center, School of Medicine, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, People's Republic of China.
Rui HuangState Key Laboratory of Cellular Stress Biology, Cancer Research Center, School of Medicine, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, People's Republic of China.
Seoyeon BokDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0001-6063-1224
Xiaohui ChenState Key Laboratory of Cellular Stress Biology, Cancer Research Center, School of Medicine, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, People's Republic of China.
Jie HanState Key Laboratory of Cellular Stress Biology, Cancer Research Center, School of Medicine, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, People's Republic of China.
Alisha R YallowitzDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0001-9502-0589
Shawon DebnathDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0003-2164-1213
Michelle CungDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-2457-4266
Zheng LingDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
Chuan-Qi ZhongCollege of Life Science, Xiamen University, Xiamen, China.ORCID 0000-0002-8354-7727
Yixang HongXiamen Cardiovascular Hospital, School of Medicine, Xiamen University, Xiamen, China.
Gang LiXiamen Cardiovascular Hospital, School of Medicine, Xiamen University, Xiamen, China.
Mascha KoenenLaboratory of Molecular Metabolism, The Rockefeller University, New York, NY, USA.ORCID 0000-0002-1024-4506
Paul CohenLaboratory of Molecular Metabolism, The Rockefeller University, New York, NY, USA.ORCID 0000-0002-2786-8585
Xinhui SuPET Center, Department of Nuclear Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Hongbin LuDepartment of Sports Medicine, Xiangya Hospital, Central South University, Changsha, People's Republic of China. hongbinlu@csu.edu.cn.
Matthew B GreenblattDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA. mag3003@med.cornell.edu.ORCID 0000-0001-9794-8532
Ren XuState Key Laboratory of Cellular Stress Biology, Cancer Research Center, School of Medicine, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, People's Republic of China. xuren526@xmu.edu.cn.ORCID 0000-0001-6578-4553
Funding
An Encyclopedia of the Adipose Tissue Secretome to Identify Mediators of Health and DiseaseRC2DK129961 · NIDDK · ROCKEFELLER UNIVERSITY · PI CHAIT, BRIAN T, COHEN, PAUL · 2021 to 2025
$9.2MDiscovery of a stem cell driving breast cancer spine metastasesR01CA282815 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Matthew Blake Greenblatt · 2024 to 2026
$2.4M"Establishing Pathways for Endothelial Support of Bone Formation with SLIT3"R01AR075585 · NIAMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI GREENBLATT, MATTHEW BLAKE · 2020 to 2024
$1.8MA skeletal stem cell orchestrating limb regenerationR01HD115274 · NICHD · WEILL MEDICAL COLL OF CORNELL UNIV · PI Matthew Blake Greenblatt, Xu Yang · 2024 to 2026
$1.8MDiscovery of a stem cell governing vertebral physiologyR01AR083462 · NIAMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Matthew Blake Greenblatt · 2024 to 2026
$1.5MNational Natural Science Foundation of China (National Science Foundation of China) 81972034National Natural Science Foundation of China (National Science Foundation of China) 82372362National Natural Science Foundation of China (National Science Foundation of China) 92068104Natural Science Foundation of Fujian Province (Fujian Provincial Natural Science Foundation) 2022J06003NCI NIH HHS R01 CA282815NIAMS NIH HHS R01 AR075585NIAMS NIH HHS R01 AR083462NICHD NIH HHS R01 HD115274NIDDK NIH HHS RC2 DK129961
Abstract
The skeleton has been suggested to function as an endocrine organ controlling whole organism energy balance, however the mediators of this effect and their molecular links remain unclear. Here, utilizing Schnurri-3
Indexed as
Adipose Tissue, WhiteBone and BonesDiet, High-FatIntercellular Signaling Peptides and ProteinsMice, KnockoutObesityOsteoblastsAdipocytesAdipose Tissue, BrownAnimalsDNA-Binding ProteinsMaleMiceMice, Inbred C57BLNerve Tissue ProteinsSignal TransductionDNA-Binding ProteinsIntercellular Signaling Peptides and ProteinsNerve Tissue ProteinsSchnurri-3 protein, mouseSlit Homolog 2 Protein
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.