Evidence map›Paper›PMID 39107186›Full record

ArticleAcademic radiology2024

Defining Breast Cryoablation Treatment Success: A Guide for the Curative and Palliative Treatment of Breast Cancer.

Monica L Huang, Deanna L Lane, Lauren Q Chang Sen, Rosalind P Candelaria, Henry M Kuerer, Kelly K Hunt, Catherine Akay, Bora Lim, Simona Shaitelman, Rosa F Hwang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Academic radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Monica L HuangDepartment of Breast Imaging, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Unit 1350, Houston, Texas 77030, USA (M.L.H., D.L.L., L.Q.C.S., R.P.C., L.S.). Electronic address: MLHuang@mdanderson.org.
Deanna L LaneDepartment of Breast Imaging, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Unit 1350, Houston, Texas 77030, USA (M.L.H., D.L.L., L.Q.C.S., R.P.C., L.S.).
Lauren Q Chang SenDepartment of Breast Imaging, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Unit 1350, Houston, Texas 77030, USA (M.L.H., D.L.L., L.Q.C.S., R.P.C., L.S.).
Rosalind P CandelariaDepartment of Breast Imaging, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Unit 1350, Houston, Texas 77030, USA (M.L.H., D.L.L., L.Q.C.S., R.P.C., L.S.).
Henry M KuererDepartment of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, Texas 77030, USA (H.M.K., K.K.H., C.A., R.F.H.).
Kelly K HuntDepartment of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, Texas 77030, USA (H.M.K., K.K.H., C.A., R.F.H.).
Catherine AkayDepartment of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, Texas 77030, USA (H.M.K., K.K.H., C.A., R.F.H.).
Bora LimDepartment of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, Texas 77030, USA (B.L.).
Simona ShaitelmanDepartment of Breast Radiation Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, Texas 77030, USA (S.S.).
Rosa F HwangDepartment of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, Texas 77030, USA (H.M.K., K.K.H., C.A., R.F.H.).
Hui ChenDepartment of Anatomical Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Unit 0085, Houston, Texas 77030, USA (H.C.).
Rajani KattaMcGovern Medical School at UTHealth Houston, 6750 West Loop South, #695, Bellaire, Texas 77401, USA (R.K.).
Lumarie SantiagoDepartment of Breast Imaging, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Unit 1350, Houston, Texas 77030, USA (M.L.H., D.L.L., L.Q.C.S., R.P.C., L.S.).

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
NCI NIH HHS P30 CA016672
6 · The paper itself

Abstract

RATIONALE AND

objectivesRecent ICE3 trial of breast cryoablation for breast cancer demonstrated 98% success rate, similar to breast-conserving surgery. However, ICE3 and other published studies did not differentiate curative from palliative treatment nor define patient-specific treatment objectives. We sought to define treatment success of curative and palliative breast cryoablation for breast cancer in meeting procedure objectives and patient-specific treatment objectives. MATERIALS AND

methodsWe conducted a retrospective analysis of breast cancer patients who underwent breast cryoablation during 2021-2024. Breast radiologists performed outpatient cryoablation using local anesthesia and argon gas cryoprobes under ultrasound or MRI guidance. Patient demographics, referral indications, tumor characteristics, procedure details, and imaging follow-up findings were analyzed. Cryoablation was categorized as curative or palliative. Treatment success was defined as achievement of both procedure and patient-specific treatment objectives.

resultsBreast cryoablation was performed for 34 lesions in 29 patients with N0M0 (n = 25), N1M0 (n = 2), N2M0 (n = 1), and N0M1 (n = 1) disease. Most tumors were invasive ductal carcinoma (IDC), low to intermediate grade, estrogen receptor (ER) and progesterone receptor (PR) positive and HER2 negative (23 tumors, 68%). Tumor size ranged from 0.4-1.9 (median 0.8) cm for curative cryoablation and 0.6-6.0 (median 1.3) cm for palliative cryoablation. For 27 patients with follow-up imaging, ablation was curative in 14 patients, 14 tumors and palliative in 13 patients, 18 lesions. Imaging follow-up time ranged from 3 to 26 (median 16) months, > 12 months in 22 of 27 patients and 25 of 32 tumors. Complications were limited to 2 cases of skin frost injury, 1 mild and 1 moderate. Treatment success was achieved in 13 of 14 patients with curative and all 13 patients with palliative cryoablation.

conclusionOur study defines treatment success for curative and palliative breast cryoablation, demonstrates breast cryoablation achieves not only procedure (technical) but also patient-specific treatment objectives without significant complications, and may serve as guide for integrating breast cryoablation in the treatment of breast cancer patients.

Indexed as

Breast NeoplasmsCryosurgeryPalliative CareAdultAgedAged, 80 and overFemaleHumansMiddle AgedRetrospective StudiesTreatment OutcomeUltrasonography, InterventionalBreast cancerCryoablationCurativePalliative

Identifiers

PMID39107186
PMCPMC12030265

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