SynthesisThorax2024
Relationship between cumulative silica exposure and silicosis: a systematic review and dose-response meta-analysis.
Synthesis in Thorax, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Adjusting for the diagnostic accuracy of CXR in the dose-response relationship between cumulative silica exposure and silicosis in miners.Occupational and environmental medicine · 2026Pooled it
- ERS Congress 2025: highlights from the Interstitial Lung Diseases Assembly.ERJ open research · 2026Article
- Experimentally recreated workplace environments contain submicron crystalline silica particles, including ultrafine particles, which have been identified in the mediastinal lymph nodes of construction workers.Occupational and environmental medicine · 2026Article
- Web application development using multiple regression analysis to predict silicosis risk among stone carvers in Nakhon Ratchasima, Thailand.Journal of occupational medicine and toxicology (London, England) · 2026Article
- Integrated ceRNA Network Analysis in Silica-Induced Pulmonary Fibrosis and Discovery of miRNA Biomarkers.Toxics · 2026Article
- Assessing Compliance with Evolving Exposure Standards: Respirable Crystalline Silica (RCS) Exposure in Western Australian Mining.International journal of environmental research and public health · 2025Article
- Effects of occupational dust exposure on the health status of workers in China.Scientific reports · 2025Article
- Risk of Pneumoconiosis in Workers Exposed to Crystalline Silica from Lava Rock Dust from Mount Etna.Journal of clinical medicine · 2025Article
- Prevalence and determinants of restrictive lung disorder among quarry workers at the Umuoghara quarry site, Ebonyi State, Nigeria: a cross-sectional study.BMC pulmonary medicine · 2025Article
- Risk characterization for silica-related silicosis and lung cancer in communities adjacent to sand and gravel extraction facilities: examining limitations in our current risk methods.Frontiers in public health · 2025Article
- Early diagnosis and survival outcomes in silicosis: a retrospective cohort study of 11,809 patients in Guangdong Province, China (1956-2020).Frontiers in public health · 2025Article
- Internal and external silica dust exposure threshold as an early screening index for silicosis: a cross-sectional study.Frontiers in public health · 2025Article
- Proteomics and Silica Dust: A Call to Reinforce Occupational History-taking.Open respiratory archivesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSilicosis, a chronic respiratory disease caused by crystalline silica exposure, is a persistent global lung health issue. No systematic review of the relationship between cumulative respirable crystalline silica (RCS) exposure and silicosis exists. UK exposure limits are currently under review. We therefore performed a systematic review and dose-response meta-analysis of this relationship.
methodsWeb of Science, Medline and Embase were searched on 24 February 2023. Studies of radiographic, autopsy or death certificate silicosis, with an estimated average follow-up of over 20 years since first employment, were included. Cumulative silicosis risk methods were compared. The relative risks (RR) of silicosis at increasing cumulative exposures were calculated and used to estimate the absolute risk reduction (ARR).
resultsEight eligible studies, including 10 cohorts, contributed 8792 cases of silicosis among 65 977 participants. Substantial differences in cumulative risk estimates between methodologies exist. Using the same method, we observed higher cumulative silicosis risks among mining compared with non-mining cohorts. A reduction from 4 to 2 mg/m³-years in cumulative RCS exposure corresponded to substantial risk reductions among miners (RR 0.23 (95% CI 0.18 to 0.29, I
conclusionDespite significant heterogeneity, our findings support a reduction in permissible exposure limits from 0.1 mg/m
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