Evidence map›Paper›PMID 39107077›Full record

ArticleBMJ open diabetes research & care2024

Risk of healthcare visits from influenza in subjects with diabetes and impacts of early vaccination.

Ronald Horswell, San Chu, Addison E Stone, Daniel Fort, Gabriel Uwaifo, Vivian A Fonseca, Elizabeth B Norton

Abstract read
In one paragraph

Article in BMJ open diabetes research & care, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ronald HorswellPennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
San ChuPennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
Addison E StoneDepartment of Microbiology & Immunology, Tulane University School of Medicine, New Orleans, Louisiana, USA.
Daniel FortOchsner Center for Outcomes and Health Services Research, New Orleans, Louisiana, USA.
Gabriel UwaifoDepartment of Endocrinology, Diabetes, and Metabolism, Ochsner Medical Center, New Orleans, Louisiana, USA.
Vivian A FonsecaMedicine, Tulane University, New Orleans, Louisiana, USA.
Elizabeth B NortonDepartment of Microbiology & Immunology, Tulane University School of Medicine, New Orleans, Louisiana, USA enorton@tulane.edu.ORCID 0000-0002-8426-3515

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Leigh Lamonica · 2012 to 2026
$69.1M
Tulane University COVID Antibody and Immunity Network (TUCAIN) SupplementU54CA260581 · NCI · TULANE UNIVERSITY OF LOUISIANA · PI ROBINSON, JAMES E · 2020 to 2024
$9.2M
Evaluation of Memory Responses and Biomarkers from a Phase IEnterotoxigenic Escherichia coli (ETEC) Intramuscular SubunitVaccine with dmLT AdjuvantR01AI166682 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI NORTON, ELIZABETH B · 2021 to 2025
$3.5M
NCI NIH HHS U54 CA260581NIAID NIH HHS R01 AI166682NIGMS NIH HHS U54 GM104940
6 · The paper itself

Abstract

introductionThe objective of this study was to determine the burden of influenza disease in patients with or without diabetes in a population of American adults to understand the benefits of seasonal vaccination. RESEARCH DESIGN AND

methodsWe performed a retrospective cohort study using electronic medical records totaling 1,117,263 from two Louisiana healthcare providers spanning January 2012 through December 2017. Adults 18 years or older with two or more records within the study period were included. The primary outcome quantified was influenza-related diagnosis during inpatient (IP) or emergency room (ER) visits and risk reduction with the timing of immunization.

resultsInfluenza-related IP or ER visits totaled 0.0122-0.0169 events per person within the 2013-2016 influenza seasons. Subjects with diabetes had a 5.6-fold more frequent influenza diagnosis for IP or ER visits than in subjects without diabetes or 3.7-fold more frequent when adjusted for demographics. Early immunization reduced the risk of influenza healthcare utilization by 66% for subjects with diabetes or 67% for subjects without diabetes when compared with later vaccination for the 2013-2016 influenza seasons. Older age and female sex were associated with a higher incidence of influenza, but not a significant change in risk reduction from vaccination.

conclusionsThe risk for influenza-related healthcare utilization was 3.7-fold higher if patients had diabetes during 2013-2016 influenza seasons. Early immunization provides a significant benefit to adults irrespective of a diabetes diagnosis. All adults, but particularly patients with diabetes, should be encouraged to get the influenza vaccine at the start of the influenza season.

Indexed as

Diabetes MellitusInfluenza, HumanInfluenza VaccinesVaccinationAdultAgedEmergency Service, HospitalFemaleFollow-Up StudiesHospitalizationHumansIncidenceMaleMiddle AgedRetrospective StudiesSeasonsInfluenza VaccinesDiabetes Mellitus, Type 2Infectious Disease MedicineVaccination

Identifiers

PMID39107077
PMCPMC11308876

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.