Evidence map›Paper›PMID 39107061›Full record

ArticleRespiratory care2024

Adaptive Pressure Control-Continuous Mandatory Ventilation Versus Volume Control-Continuous Mandatory Ventilation: Factors Associated With Initiation, Maintenance, and Adjustment.

Linh N Tran, Jared E Rosen, Alex K Pearce, Atul Malhotra, Russell G Buhr, Ragan Saggar, Jeffrey A Davis, Jennifer L Martin, Biren B Kamdar

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory care, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Linh N TranDivision of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, School of Medicine, La Jolla, California. Lit004@ucsd.edu.
Jared E RosenDivision of Pulmonary, Critical Care and Sleep Medicine, University of California, Davis, School of Medicine, Sacramento, California.
Alex K PearceDivision of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, School of Medicine, La Jolla, California.
Atul MalhotraDivision of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, School of Medicine, La Jolla, California.
Russell G BuhrDivision of Pulmonary, Critical Care Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California; and Center for the Study of Healthcare Innovation, Implementation, and Policy, Health Services Research and Development, Greater Los Angeles Veterans Affairs Healthcare System, Los Angeles, California.
Ragan SaggarDivision of Pulmonary, Critical Care Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.
Jeffrey A DavisDivision of Pulmonary, Critical Care Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.
Jennifer L MartinVA Greater Los Angeles Healthcare System, Geriatric Research, Education and Clinical Center, Los Angeles, California; and Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.
Biren B KamdarDivision of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, School of Medicine, La Jolla, California; and VA San Diego Healthcare System, La Jolla, California.

Funding

The Effect of Nanoparticle Encapsulated Resveratrol on Treatment of PeriodontitisKL2TR001882 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Elizabeta Nemeth · 2016 to 2026
$13.1M
Is Obstructive Sleep Apnea Important in the Development of Alzheimer's DiseaseR01AG063925 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2020 to 2024
$3.7M
Underlying mechanisms of obesity-induced obstructive sleep apneaR01HL148436 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Atul Malhotra · 2020 to 2026
$3.4M
Sleep Apnea Endophenotypes: One Size Does Not Fit AllR01HL154926 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2021 to 2025
$3.3M
The cardiovascular consequences of sleep apnea plus COPD (Overlap syndrome)R01HL166485 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Atul Malhotra · 2023 to 2026
$3.1M
VentNet: A Real-Time Multimodal Data Integration Model for Prediction of Respiratory Failure in Patients with COVID-19R01HL157985 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL, NEMATI, SHAMIM · 2022 to 2025
$2.9M
Developing a Diverse Next Generation of Leaders in Respiratory ScienceT32HL166127 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Laura Elise Crotty Alexander, Atul Malhotra · 2023 to 2026
$1.6M
Multicomponent intervention to improve delirium and sleep-wake rhythms in older ICU patientsK76AG059936 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KAMDAR, BIREN BHARAT · 2018 to 2022
$1.4M
Sleep health in special populationsK24HL143055 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MARTIN, JENNIFER L · 2018 to 2025
$898k
NCATS NIH HHS KL2 TR001882NHLBI NIH HHS K24 HL143055NHLBI NIH HHS L30 HL134025NHLBI NIH HHS R01 HL148436NHLBI NIH HHS R01 HL154926NHLBI NIH HHS R01 HL157985NHLBI NIH HHS R01 HL166485NHLBI NIH HHS T32 HL166127NIA NIH HHS K76 AG059936NIA NIH HHS R01 AG063925
6 · The paper itself

Abstract

backgroundAdaptive pressure control-continuous mandatory ventilation (APC-CMV) is a frequently utilized ventilator mode in ICU settings. This analysis compared APC-CMV and traditional volume control-continuous mandatory ventilation (VC-CMV) mode, describing factors associated with initiation, maintenance, and changes in settings of each mode.

methodsWe analyzed ventilator data from a retrospective electronic health record data set collected as part of a quality improvement project in a single academic ICU. The majority ventilator mode was defined as the mode comprising the highest proportion of mechanical ventilation time. Multivariable logistic regression was used to identify variables associated with initial and majority APC-CMV or VC-CMV modes. Wilcoxon rank-sum tests were used to compare ventilator setting changes/d and sedation as a function of APC-CMV and VC-CMV majority modes.

resultsAmong 1,213 subjects initiated on mechanical ventilation from January 2013-March 2017, 68% and 24% were initiated on APC-CMV and VC-CMV, respectively, which composed 62% and 21% of the majority ventilator modes. Age, sex, race, and ethnicity were not associated with the initial or majority APC-CMV or VC-CMV modes. Subjects initiated on APC-CMV spent 88% of the mechanical ventilation time on APC-CMV mode. Compared to VC-CMV, subjects with APC-CMV majority mode experienced more ventilator setting changes/d (1.1 vs 0.8,

conclusionsAPC-CMV was highly utilized in the medical ICU. Subjects on APC-CMV had more ventilator setting changes/d than those on VC-CMV. APC-CMV offered no advantage of reduced setting adjustments or less sedation compared to VC-CMV.

Indexed as

Intensive Care UnitsRespiration, ArtificialAdultAgedFemaleHumansLogistic ModelsMaleMiddle AgedQuality ImprovementRetrospective StudiesTidal Volumeartificial: ICUscritical illnessmechanical: respirationobservational studyrespiratory insufficiencyventilators

Identifiers

PMID39107061
PMCPMC11572997

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.